Recombinant Proteins
Product List
ELOB Mouse
Elongin B Mouse Recombinant
ELOB Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain of 141 amino acids ( 1-118 a.a.) having a molecular mass of 15.6 kDa. The Recombinant Mouse ELOB is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
ELOB Human
Elongin-B Polypeptide 2 Human Recombinant
TCEA1 Human
Transcription Elongation Factor A (SII)-1 Human Recombinant
TCEA1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
TCEA2 Human
Transcription Elongation Factor A (SII)-2 Human Recombinant
TCEA2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
TCEAL1 Human
Transcription Elongation Factor A (SII)-Like 1 Human Recombinant
The TCEAL1 is purified by proprietary chromatographic techniques.
TCEAL3 Human
Transcription Elongation Factor A (SII)-Like 3 Human Recombinant
TCEAL3 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
TCEAL7 Human
Transcription Elongation Factor A (SII)-Like 7 Human Recombinant
TCEAL7 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
TCEAL8 Human
Transcription Elongation Factor A (SII)-Like 8 Human Recombinant
TCEAL8 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
TCEB1 Human
Transcription Elongation Factor B Polypeptide 1 Human Recombinant
TCEB1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
Transcription elongation factors are proteins that facilitate the elongation phase of transcription by RNA polymerase II (Pol II). They ensure the efficient and accurate synthesis of RNA by aiding the polymerase in overcoming various obstacles, such as DNA secondary structures and nucleosomes . These factors can be classified into several groups based on their functions and interactions with Pol II, including general elongation factors, chromatin modifiers, and RNA processing factors .
Key Biological Properties: Transcription elongation factors are essential for the proper functioning of Pol II during the elongation phase of transcription. They help maintain the stability of the transcription complex and ensure the fidelity of RNA synthesis .
Expression Patterns: The expression of transcription elongation factors varies across different tissues and developmental stages. For example, the elongation factor TFIIS is dynamically regulated and accumulates during heat stress in plants .
Tissue Distribution: These factors are ubiquitously expressed in various tissues, reflecting their fundamental role in gene expression. However, their levels can be modulated in response to specific cellular conditions and external stimuli .
Primary Biological Functions: The primary function of transcription elongation factors is to facilitate the elongation phase of transcription by assisting Pol II in synthesizing RNA. They help Pol II overcome obstacles such as DNA secondary structures and nucleosomes, ensuring efficient and accurate RNA synthesis .
Role in Immune Responses and Pathogen Recognition: Transcription elongation factors play a crucial role in regulating the expression of genes involved in immune responses and pathogen recognition. By modulating the transcription of these genes, they help the immune system respond effectively to infections and other threats .
Mechanisms with Other Molecules and Cells: Transcription elongation factors interact with various molecules and cellular components to facilitate the elongation phase of transcription. For example, elongation factor Tu (EF-Tu) delivers aminoacyl-tRNA to the ribosome during translation elongation .
Binding Partners: These factors often interact with other proteins, such as chromatin modifiers and RNA processing factors, to regulate transcription elongation. For instance, the elongation factor TFIIS interacts with RNA polymerase II to enhance its nuclease activity and facilitate transcriptional reprogramming during stress responses .
Downstream Signaling Cascades: Transcription elongation factors can influence downstream signaling cascades by regulating the expression of key genes involved in various cellular processes. This regulation can impact cell growth, differentiation, and response to environmental stimuli .
Transcriptional Regulation: The expression of transcription elongation factors is tightly regulated at the transcriptional level. Various transcription factors and regulatory elements control their gene expression in response to cellular conditions and external stimuli .
Post-Translational Modifications: Post-translational modifications, such as phosphorylation and acetylation, play a crucial role in regulating the activity of transcription elongation factors. These modifications can alter their interactions with other proteins and their ability to facilitate transcription elongation .
Biomedical Research: Transcription elongation factors are valuable tools in biomedical research for studying gene expression and regulation. They can be used to investigate the mechanisms underlying various diseases and to identify potential therapeutic targets .
Diagnostic Tools: The expression levels of transcription elongation factors can serve as biomarkers for certain diseases. For example, dysregulation of these factors has been linked to various cancers and developmental disorders .
Therapeutic Strategies: Targeting transcription elongation factors holds promise for developing novel therapeutic strategies. Modulating their activity can potentially treat diseases associated with dysregulated gene expression, such as cancer and autoimmune disorders .
Development: Transcription elongation factors play a critical role in regulating gene expression during development. They ensure the proper transcription of genes involved in cell growth, differentiation, and tissue formation .
Aging and Disease: The activity of transcription elongation factors can be affected by aging and disease. Dysregulation of these factors has been implicated in various age-related diseases, including neurodegenerative disorders and cancer .
