Recombinant Proteins
Product List
BIN2 Human
Bridging Integrator 2 Human Recombinant
BIN2 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (1-597 a.a.) and fused to a 6 aa His Tag at C-terminus containing a total of 606 amino acids and having a molecular mass of 66.1kDa.
BIN2 shows multiple bands between 70-100kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
BIN1 Human
Bridging Integrator 1 Human Recombinant
Introduction
Key Biological Properties: BIN1 is involved in several cellular processes, including endocytosis, membrane recycling, cytoskeletal regulation, DNA repair, cell cycle progression, and apoptosis .
Expression Patterns: BIN1 is commonly expressed in terminally differentiated normal tissues and is usually undetectable in refractory or metastatic cancer tissues .
Tissue Distribution: BIN1 is most abundantly expressed in the brain and muscle . It is also present in other tissues, including the heart and immune cells .
Primary Biological Functions: BIN1 plays a crucial role in endocytosis and membrane recycling, cytoskeletal regulation, DNA repair, cell cycle progression, and apoptosis .
Role in Immune Responses and Pathogen Recognition: BIN1 is involved in immune responses by regulating the endocytosis and trafficking of immune receptors . It also plays a role in pathogen recognition by modulating the immune signaling pathways .
Mechanisms with Other Molecules and Cells: BIN1 interacts with various molecules and cells through its SH3 domain, which binds to proline-rich motifs in other proteins . This interaction is crucial for its role in endocytosis and membrane recycling .
Binding Partners: BIN1 binds to several proteins, including MYC, clathrin, and dynamin . These interactions are essential for its function in cellular processes such as endocytosis and cytoskeletal regulation .
Downstream Signaling Cascades: BIN1 is involved in several downstream signaling cascades, including those regulating apoptosis and cell cycle progression . It mediates apoptosis via c-MYC in transformed primary cells .
Transcriptional Regulation: The expression of BIN1 is regulated at the transcriptional level by various transcription factors, including MYC .
Post-Translational Modifications: BIN1 undergoes several post-translational modifications, including phosphorylation and ubiquitination . These modifications regulate its activity and stability .
Biomedical Research: BIN1 is a valuable tool in biomedical research due to its role in various cellular processes and diseases . It is used to study cancer, Alzheimer’s disease, myopathy, heart failure, and inflammation .
Diagnostic Tools: BIN1 serves as a biomarker for several diseases, including cancer and Alzheimer’s disease . Its differential expression in normal and diseased tissues makes it a useful diagnostic tool .
Therapeutic Strategies: BIN1 is a potential therapeutic target for diseases such as cancer and Alzheimer’s disease . Strategies to modulate its expression and activity are being explored for therapeutic purposes .
Development: BIN1 plays a crucial role in development by regulating cell cycle progression and apoptosis . Its expression is essential for the proper development of various tissues, including the brain and muscle .
Aging and Disease: BIN1 is involved in aging and age-related diseases, such as Alzheimer’s disease . Its role in endocytosis and membrane recycling is crucial for maintaining cellular homeostasis during aging .
Disease: BIN1 is implicated in several diseases, including cancer, Alzheimer’s disease, myopathy, and heart failure . Its differential expression and activity in normal and diseased tissues make it a critical player in disease progression .
