Recombinant Proteins
Product List
SCGB1D1 Human
Secretoglobin Family 1D, Member 1 Human Recombinant
SCGB2A2 Human, HEK
Mammaglobin-A Human Recombinant, HEK
SCGB3A2 Human
Secretoglobin Family 3A Member 2 Human Recombinant
Introduction
Secretoglobins (SCGBs) are a family of small, alpha-helical, disulfide-linked, dimeric proteins found exclusively in mammals . They were previously known as the Uteroglobin/Clara cell 10-kDa family, named after their founding member Uteroglobin . The family is classified into several subfamilies based on sequence homology .
Key Biological Properties: Secretoglobins are relatively small, secreted proteins with a molecular weight of approximately 10 kDa . They form dimers through disulfide bridges and have a large hydrophobic pocket that can bind small to medium-sized ligands like steroids and phospholipids .
Expression Patterns and Tissue Distribution: Secretoglobins are predominantly expressed in secretory tissues of barrier organs such as the lungs, lacrimal glands, salivary glands, prostate glands, and uterus . They are highly abundant in the respiratory tract and can also be detected in malignant tissues .
Primary Biological Functions: Secretoglobins play a crucial role in immunoregulatory and anti-inflammatory processes . They are involved in modulating inflammation, tissue repair, and tumorigenesis .
Role in Immune Responses and Pathogen Recognition: Secretoglobins are embedded in Th1 and Th2 immune responses and are expressed in a manner dependent on cell maturation . They react to cytokines and are critical elements of innate immune control at epithelial barriers .
Mechanisms with Other Molecules and Cells: Secretoglobins interact with various molecules and cells through their hydrophobic pockets, which can bind steroids and phospholipids .
Binding Partners and Downstream Signaling Cascades: For example, SCGB3A2 chaperones lipopolysaccharides (LPS) to the cytosol, activating caspase-11 and the non-canonical inflammasome pathway, leading to pyroptosis .
Regulatory Mechanisms Controlling Expression and Activity: Secretoglobins are differentially regulated by inflammatory cytokines . They are embedded in Th1 and Th2 immune responses and are expressed in a manner dependent on cell maturation .
Transcriptional Regulation and Post-Translational Modifications: The expression of secretoglobins is controlled by various transcription factors and signaling pathways, including NFκB/RelA-TGFβ signaling .
Biomedical Research: Secretoglobins are used in research to understand their role in immune regulation and inflammation .
Diagnostic Tools: Due to their high abundance in the respiratory tract and involvement in diseases, secretoglobins can serve as biomarkers for diagnostic assessment of epithelial activity .
Therapeutic Strategies: Secretoglobins have potential therapeutic applications in treating inflammatory and autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease .
Role Throughout the Life Cycle: Secretoglobins play a role in various stages of life, from development to aging and disease . They are involved in the modulation of inflammation, tissue repair, and tumorigenesis, making them critical for maintaining homeostasis and responding to pathological conditions .
