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Product List
DCN Human
Decorin Human Recombinant
DCN Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 350 amino acids (31-359 a.a) and having a molecular mass of 38.6kDa.
DCN is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
DCN is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Shipped with Ice Packs 
Cat. No.
BT29188
Source
Escherichia Coli.
Appearance
Sterile filtered colorless solution.
DCN Human, Sf9
Decorin Human Recombinant, Sf9
DCN produced in Sf9 Baculovirus cells is a single,
glycosylated polypeptide chain containing 335 amino acids (31-359a.a.) and
having a molecular mass of 37.1kDa.
(Molecular size on SDS-PAGE will appear at
approximately 40-57kDa).
DCN is expressed with a 6 amino acid His tag at
C-Terminus and purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT29242
Source
Sf9,
Baculovirus cells.
Appearance
Sterile filtered colorless solution.
DCN Mouse
Decorin Mouse Recombinant
DCN produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (17-354 a.a.) and fused to a 6 aa His Tag at C-terminus containing a total of 344 amino acids and having a molecular mass of 38.8kDa.
DCN shows multiple bands between 40-57kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
DCN shows multiple bands between 40-57kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
Shipped with Ice Packs
Cat. No.
BT29308
Source
Sf9, Baculovirus cells.
Appearance
Sterile filtered colorless solution.
Introduction
Definition and Classification
Decorin is a small leucine-rich proteoglycan (SLRP) that belongs to the class I SLRP family. It is encoded by the DCN gene and is characterized by a core protein containing leucine repeats and a glycosaminoglycan (GAG) chain, which can be either chondroitin sulfate (CS) or dermatan sulfate (DS) . Decorin is a component of the extracellular matrix (ECM) and plays a crucial role in collagen fibrillogenesis and tissue organization .
Biological Properties
Decorin exhibits several key biological properties:
- Expression Patterns: Decorin is expressed in various tissues, including connective tissues, skin, bone, cartilage, ligaments, and blood vessels . It is also found in body fluids such as plasma and the aqueous and vitreous humor of the eye .
- Tissue Distribution: It is predominantly synthesized by fibroblasts, endothelial cells, and smooth muscle cells . Decorin is widely distributed in the stromal tissues and is essential for maintaining the structural integrity of the ECM .
Biological Functions
Decorin has multiple biological functions:
- Primary Functions: It regulates collagen fibrillogenesis, ensuring proper collagen fiber formation and tissue organization . Decorin also modulates cell growth by interacting with growth factors and receptor tyrosine kinases .
- Immune Responses and Pathogen Recognition: Decorin plays a role in immune responses by modulating inflammation and interacting with immune cells . It can bind to pathogens and facilitate their recognition by the immune system .
Modes of Action
Decorin interacts with various molecules and cells through several mechanisms:
- Binding Partners: Decorin binds to collagen, growth factors, and receptor tyrosine kinases such as EGFR, Met, IGF-IR, VEGFR, and PDGFR . These interactions regulate cell proliferation, migration, and differentiation .
- Downstream Signaling Cascades: Decorin can initiate signaling pathways that lead to cell cycle arrest, apoptosis, and autophagy . It also induces the degradation of receptor tyrosine kinases through caveosomal internalization .
Regulatory Mechanisms
The expression and activity of decorin are controlled by various regulatory mechanisms:
- Transcriptional Regulation: Decorin gene expression is regulated by transcription factors and signaling pathways that respond to cellular and environmental cues .
- Post-Translational Modifications: Decorin undergoes post-translational modifications such as glycosylation, which are essential for its proper function and interaction with other molecules .
Applications
Decorin has several applications in biomedical research and therapeutic strategies:
- Biomedical Research: Decorin is studied for its role in tissue engineering, wound healing, and fibrosis . It is also investigated for its potential as an anti-cancer agent due to its ability to inhibit tumor growth and metastasis .
- Diagnostic Tools and Therapeutic Strategies: Decorin can be used as a biomarker for certain diseases and as a therapeutic agent to modulate ECM remodeling and inflammation .
Role in the Life Cycle
Decorin plays a significant role throughout the life cycle:
- Development: During development, decorin is crucial for proper tissue formation and organization .
- Aging and Disease: In aging, decorin helps maintain tissue homeostasis and prevent fibrosis . In diseases such as cancer and fibrosis, decorin’s regulatory functions are often disrupted, leading to pathological changes .
