Recombinant Proteins
Product List
REG1A Human
Regenerating Islet-Derived 1 Alpha Human Recombinant
REG1B Human
Regenerating Islet-Derived 1 Beta Human Recombinant
REG3A Human
Regenerating Islet-Derived 3 Alpha Human Recombinant
REG4 Human
Regenerating Islet-Derived 4 Human Recombinant
REG4 Human, Sf9
Regenerating Islet-Derived 4 Human Recombinant, Sf9
REG4 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain (23-158 a.a.) and fused to a 9 aa His Tag at C-terminus containing a total of 145 amino acids and having a molecular mass of 17kDa.
REG4 shows multiple bands between 13.5-18kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
Sterile filtered colorless solution.
Introduction
Regenerating islet-derived (Reg) proteins are a family of small, secreted C-type lectins initially identified in the pancreas. They are involved in various physiological processes, including cell proliferation, differentiation, and tissue regeneration. The Reg family is classified into several subfamilies, such as Reg1, Reg2, Reg3, and Reg4, each with distinct members like Reg1A, Reg1B, Reg3A, and Reg4 .
Key Biological Properties: Reg proteins exhibit pro-proliferative, anti-apoptotic, differentiation-inducing, and bactericidal properties .
Expression Patterns: These proteins are expressed in various tissues, including the pancreas, gastrointestinal tract, and liver. Their expression is often upregulated in response to injury, inflammation, and certain diseases .
Tissue Distribution: Reg proteins are predominantly found in the pancreas, particularly in the islets of Langerhans, but are also present in other tissues such as the gastrointestinal tract and liver .
Primary Biological Functions: Reg proteins play crucial roles in tissue repair, cell proliferation, and apoptosis inhibition. They are also involved in antimicrobial defense and inflammation regulation .
Role in Immune Responses: Reg proteins contribute to immune responses by recognizing and binding to pathogens, thereby facilitating their clearance .
Pathogen Recognition: These proteins can bind to bacterial cell walls, enhancing the host’s ability to combat infections .
Mechanisms with Other Molecules and Cells: Reg proteins interact with various receptors and signaling molecules to exert their effects. For example, Reg3A binds to bacterial peptidoglycan, leading to bacterial cell lysis .
Binding Partners: Reg proteins have several binding partners, including cell surface receptors and extracellular matrix components .
Downstream Signaling Cascades: Upon binding to their receptors, Reg proteins activate downstream signaling pathways such as the JAK-STAT, PI3K-Akt, and NF-κB pathways, which mediate their biological effects .
Regulation of Expression and Activity: The expression of Reg proteins is tightly regulated at the transcriptional and post-transcriptional levels. Factors such as cytokines, growth factors, and stress signals can modulate their expression .
Transcriptional Regulation: Transcription factors like STAT3 and NF-κB play significant roles in regulating the expression of Reg genes .
Post-Translational Modifications: Reg proteins undergo various post-translational modifications, including glycosylation and phosphorylation, which can affect their stability and activity .
Biomedical Research: Reg proteins are valuable tools in biomedical research for studying cell proliferation, differentiation, and tissue regeneration .
Diagnostic Tools: Due to their altered expression in various diseases, Reg proteins serve as potential biomarkers for conditions such as diabetes, cancer, and inflammatory diseases .
Therapeutic Strategies: Reg proteins hold promise as therapeutic agents for promoting tissue repair and regeneration in diseases like diabetes and inflammatory bowel disease .
Development: Reg proteins are involved in the development and differentiation of various tissues, including the pancreas and gastrointestinal tract .
Aging: The expression of Reg proteins can change with age, potentially influencing tissue repair and regeneration processes .
Disease: Dysregulation of Reg protein expression is associated with several diseases, including diabetes, cancer, and neurodegenerative disorders .
