Recombinant Proteins
Product List
CEBP Alpha Human
CCAAT/enhancer binding protein CEBP Alpha Human Recombinant
The Recombinant Human CEBP-a was purified by proprietary chromatographic techniques.
CEBP Gamma Human
CCAAT/enhancer binding protein C/EBP Gamma Recombinant Human
The DNA binding domain of CEBP-g was purified by proprietary chromatographic techniques.
Introduction
CCAAT/Enhancer-Binding Proteins (CEBP) are a family of transcription factors that play crucial roles in regulating gene expression in various biological processes. The CEBP family consists of six members: CEBPA, CEBPB, CEBPC, CEBPD, CEBPE, and CEBPZ . These proteins are characterized by a highly conserved basic leucine zipper (bZIP) domain at the C-terminus, which is essential for dimerization and DNA binding .
Key Biological Properties: CEBP proteins are involved in cell differentiation, proliferation, metabolism, and immune responses . They function as transcription factors by binding to specific DNA sequences and regulating the expression of target genes .
Expression Patterns and Tissue Distribution: CEBP proteins are expressed in various tissues, including the liver, adipose tissue, hematopoietic cells, and the brain . For example, CEBPA is predominantly expressed in the liver and adipose tissue, while CEBPB is found in the liver, adipose tissue, and immune cells . CEBPD is expressed in the liver, adipose tissue, and brain .
Primary Biological Functions: CEBP proteins regulate various biological processes, including cell differentiation, proliferation, and metabolism . They play a crucial role in the development and function of the immune system by regulating the expression of genes involved in immune responses and pathogen recognition .
Role in Immune Responses and Pathogen Recognition: CEBP proteins are involved in the regulation of genes that encode cytokines, chemokines, and other immune-related molecules . For example, CEBPB regulates the expression of interleukin-6 (IL-6), a cytokine involved in the inflammatory response .
Mechanisms with Other Molecules and Cells: CEBP proteins interact with other transcription factors, co-activators, and co-repressors to regulate gene expression . They can form homodimers or heterodimers with other CEBP family members or other transcription factors, such as c-Fos and c-Jun .
Binding Partners and Downstream Signaling Cascades: CEBP proteins bind to specific DNA sequences in the promoters of target genes and recruit co-activators or co-repressors to modulate gene expression . They also interact with other signaling molecules to regulate downstream signaling cascades involved in cell differentiation, proliferation, and immune responses .
Transcriptional Regulation: The expression of CEBP genes is regulated by various transcription factors, hormones, and signaling pathways . For example, CEBPA expression is regulated by the transcription factors PU.1 and GATA-1 .
Post-Translational Modifications: CEBP proteins undergo various post-translational modifications, including phosphorylation, acetylation, and sumoylation, which modulate their activity and stability . These modifications can affect the DNA-binding affinity, dimerization, and interaction with other proteins .
Biomedical Research: CEBP proteins are studied extensively in biomedical research due to their roles in cell differentiation, proliferation, and immune responses . They are used as markers for studying the development and function of various tissues and organs .
Diagnostic Tools and Therapeutic Strategies: CEBP proteins are potential diagnostic markers and therapeutic targets for various diseases, including cancer, metabolic disorders, and inflammatory diseases . For example, CEBPA mutations are associated with acute myeloid leukemia (AML), and targeting CEBPA signaling pathways is being explored as a therapeutic strategy for AML .
Development to Aging and Disease: CEBP proteins play essential roles throughout the life cycle, from development to aging and disease . During development, they regulate the differentiation and proliferation of various cell types . In adulthood, they maintain tissue homeostasis and regulate immune responses . Dysregulation of CEBP proteins is associated with various diseases, including cancer, metabolic disorders, and inflammatory diseases .
