Recombinant Proteins
Product List
CNPY1 Human
Canopy FGF Signaling Regulator 1 Human Recombinant
CNPY1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CNPY3 Human
Canopy 3 Homolog Human Recombinant
CNPY4 Human
Canopy FGF Signaling Regulator 4 Human Recombinant
CNPY4 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques..
Introduction
The Canopy FGF Signaling Regulator, also known as CNPY (Canopy), is a family of proteins that play a crucial role in the regulation of fibroblast growth factor (FGF) signaling. These proteins are classified into several types, including CNPY1, CNPY2, CNPY3, CNPY4, and CNPY5 . Each type has distinct functions and is involved in various biological processes.
Key Biological Properties: CNPY proteins are characterized by their ability to bind to and regulate FGF receptors. They contain specific domains that facilitate their interaction with other proteins and cellular components .
Expression Patterns and Tissue Distribution: The expression of CNPY proteins varies across different tissues. For instance, CNPY2 is highly expressed in the heart, lung, and liver . CNPY3 is predominantly found in immune cells and is involved in the trafficking of toll-like receptors (TLRs) .
Primary Biological Functions: CNPY proteins are essential for the proper functioning of FGF signaling pathways. They play a role in cell proliferation, differentiation, and survival .
Role in Immune Responses and Pathogen Recognition: CNPY3, in particular, is involved in the immune response by regulating the trafficking and activation of TLRs, which are critical for pathogen recognition and initiating immune responses .
Mechanisms with Other Molecules and Cells: CNPY proteins interact with FGF receptors and other signaling molecules to modulate their activity. For example, CNPY1 interacts with FGFR1 to enhance FGF signaling .
Binding Partners and Downstream Signaling Cascades: CNPY proteins bind to various partners, including HSP90B1 and TLRs, to facilitate their proper folding and trafficking . This interaction triggers downstream signaling cascades such as the PI3K/AKT and MAPK pathways .
Regulatory Mechanisms Controlling Expression and Activity: The expression and activity of CNPY proteins are regulated at multiple levels, including transcriptional and post-translational modifications .
Transcriptional Regulation: Specific transcription factors bind to the promoter regions of CNPY genes to regulate their expression .
Post-Translational Modifications: CNPY proteins undergo various post-translational modifications, such as phosphorylation, which modulate their activity and interactions with other proteins .
Biomedical Research: CNPY proteins are studied for their role in various diseases, including cancer and cardiovascular diseases .
Diagnostic Tools: The expression levels of CNPY proteins can serve as biomarkers for certain diseases .
Therapeutic Strategies: Targeting CNPY proteins and their pathways offers potential therapeutic strategies for treating diseases such as cancer and inflammatory disorders .
Role Throughout the Life Cycle: CNPY proteins play a significant role throughout the life cycle, from development to aging and disease .
Development: During embryonic development, CNPY proteins are involved in the proper formation of tissues and organs .
Aging and Disease: Dysregulation of CNPY proteins is associated with various age-related diseases, including neurodegenerative disorders and cardiovascular diseases .
