Recombinant Proteins
Product List
RCN1 Human
Reticulocalbin 1 Human Recombinant
RCN2 Human
Reticulocalbin 2 Human Recombinant
RCN2 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
RCN3 Human
Reticulocalbin 3 Human Recombinant
RCN3 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
Reticulocalbin (RCN) is an endoplasmic reticulum (ER)-resident calcium-binding protein characterized by the presence of six EF-hand motifs . It belongs to the CREC family of proteins, which are involved in calcium-binding and regulation within the secretory pathway . Reticulocalbin is encoded by the RCN1 gene in humans .
Key Biological Properties: Reticulocalbin is known for its calcium-binding capabilities, facilitated by its six EF-hand motifs . This protein is localized in the lumen of the ER, where it plays a role in calcium-dependent activities .
Expression Patterns: Reticulocalbin exhibits a ubiquitous expression pattern in both mouse and human tissues . It is expressed in various cell types, including endothelial and prostate cancer cell lines .
Tissue Distribution: Reticulocalbin is widely distributed across different tissues, reflecting its fundamental role in cellular functions .
Primary Biological Functions: Reticulocalbin is involved in the regulation of calcium-dependent activities within the ER lumen or post-ER compartments . It may also play a role in protein folding and quality control within the ER .
Role in Immune Responses and Pathogen Recognition: While specific roles in immune responses and pathogen recognition are not well-documented, reticulocalbin’s involvement in calcium signaling suggests it may influence immune cell functions indirectly .
Mechanisms with Other Molecules and Cells: Reticulocalbin interacts with various molecules within the ER, including other calcium-binding proteins and chaperones . It may also interact with signaling molecules involved in calcium homeostasis .
Binding Partners: Reticulocalbin binds to calcium ions through its EF-hand motifs, which are crucial for its function . It may also interact with other ER-resident proteins to facilitate its role in calcium regulation .
Downstream Signaling Cascades: Reticulocalbin’s role in calcium regulation suggests it may influence downstream signaling pathways that depend on calcium as a second messenger .
Transcriptional Regulation: The expression of reticulocalbin is regulated at the transcriptional level, although specific transcription factors involved are not well-characterized .
Post-Translational Modifications: Reticulocalbin undergoes post-translational modifications, including phosphorylation, which may influence its activity and interactions with other proteins .
Biomedical Research: Reticulocalbin is a subject of interest in biomedical research due to its role in calcium regulation and potential involvement in various diseases .
Diagnostic Tools: Reticulocalbin has been identified as a potential biomarker for diseases such as chronic obstructive pulmonary disease (COPD) and atherosclerosis .
Therapeutic Strategies: Targeting reticulocalbin and its pathways may offer therapeutic potential for diseases characterized by dysregulated calcium homeostasis .
Development: Reticulocalbin plays a role in cellular development by regulating calcium-dependent processes essential for cell differentiation and growth .
Aging and Disease: Dysregulation of reticulocalbin expression or function has been associated with various diseases, including cancer and cardiovascular diseases . Its role in maintaining calcium homeostasis is crucial for cellular health throughout the life cycle .
