RCN2 Human
Description
RCN2 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
YMTEFVIQEA LEEHDKNGDG FVSLEEFLGD YRWDPTANED PEWILVEKDR FVNDYDKDND GRLDPQELLP WVVPNNQGIA QEEALHLIDE MDLNGDKKLS EEEILENPDL FLTSEATDYG RQLHDDYFYH DEL.
Product Science Overview
RCN2 contains six conserved regions that are similar to a high-affinity calcium-binding motif known as the EF-hand . This motif is essential for its ability to bind calcium ions, which is critical for various cellular processes. The protein is encoded by the RCN2 gene, which is located on chromosome 15 in humans .
The primary function of RCN2 is to regulate calcium levels within the ER, which is vital for maintaining cellular homeostasis and proper functioning of various cellular activities . Calcium ions play a significant role in numerous cellular processes, including muscle contraction, neurotransmitter release, and enzyme activity.
RCN2 has been associated with several diseases and conditions. Notably, it has been linked to Nonmucinous Bronchioloalveolar Adenocarcinoma and Bardet-Biedl Syndrome . The gene encoding RCN2 maps to the same region as type 4 Bardet-Biedl syndrome, suggesting a possible causative role for this gene in the disorder .
Recombinant Human RCN2 protein is a human full-length protein expressed in Escherichia coli. It is typically purified to a high degree of purity (>90%) and is suitable for various applications, including SDS-PAGE and mass spectrometry (MS) . The recombinant form of RCN2 retains its calcium-binding properties and is used in research to study its function and role in various diseases.
The recombinant form of RCN2 is widely used in research to understand its role in calcium homeostasis and its involvement in diseases. It is also used to study the protein’s structure and function, which can provide insights into potential therapeutic targets for conditions associated with calcium dysregulation.
