RCN1 Human

Reticulocalbin 1 contains six conserved regions that are similar to a high-affinity calcium-binding motif known as the EF-hand . The EF-hand motif is a helix-loop-helix structural domain that can bind calcium ions, which is essential for the protein’s function. The high conservation of amino acid residues outside these motifs suggests that Reticulocalbin 1 may have additional biochemical functions beyond calcium binding .

The RCN1 gene is located on chromosome 11 in humans . It is expressed in various tissues, including the corpus epididymis, stromal cells of the endometrium, periodontal fibers, seminal vesicles, and several other tissues . The protein’s expression pattern indicates its involvement in diverse physiological processes.

Reticulocalbin 1 is involved in post-translational protein modification, in utero embryonic development, and camera-type eye development . Its role in the ER suggests that it may be involved in the folding and quality control of newly synthesized proteins, as well as in the regulation of calcium homeostasis within the ER .

Mutations or dysregulation of the RCN1 gene can potentially lead to various diseases, although specific clinical conditions directly associated with Reticulocalbin 1 are still under investigation. The protein’s involvement in critical cellular processes makes it a potential target for therapeutic interventions in diseases related to ER stress and calcium homeostasis.

Human recombinant Reticulocalbin 1 is used in research to study its function and role in cellular processes. Recombinant proteins are produced through genetic engineering techniques, allowing scientists to investigate the protein’s properties and interactions in a controlled environment. This research can provide insights into the protein’s role in health and disease, potentially leading to the development of new therapeutic strategies.