Recombinant Proteins
Product List
HSA Fatty Acid free
Human Serum Albumin Recombinant, Fatty Acid Free
Sterile Filtered clear yellowish solution.
HSA Recombinant, HEK
Human Serum Albumin Recombinant, HEK
The HSA is purified by proprietary chromatographic techniques.
HSA Recombinant, Plant
Human Serum Albumin Recombinant, Plant
HSA Human Recombinant produced in Plant is a non-glycosylated, polypeptide chain containing 585 amino acids and having a molecular mass of 67 kDa. The optimum concentration for recombinant Albumin to be used in cell culture ranges between 0.5gr to 2gr per liter. The recombinant Albumin is purified by proprietary chromatographic techniques.
HSA, Pichia Pastoris
Human Serum Albumin Recombinant, Pichia
The recombinant Albumin is purified by proprietary chromatographic techniques.
HSA, Sf9
Serum Albumin Human, Sf9
HSA shows multiple bands between 50-70kDa on SDS-PAGE, reducing conditions and purified by proprietary chromatographic techniques.
Prealbumin Human
Transthyretin Human
Human Transthyretin dimer protein produced in Human plasma having a molecular mass of 30kD. Under certain conditions it may be shown as a monomer (15kD) or a tetramer (60kD).
Human serum.
Sterile Filtered White lyophilized (freeze-dried) powder.
Transthyretin Human
Prealbumin Human Recombinant
Introduction
Albumin is a family of globular proteins, the most common of which are the serum albumins. These proteins are water-soluble, moderately soluble in concentrated salt solutions, and experience heat denaturation . Albumins are commonly found in blood plasma and differ from other blood proteins in that they are not glycosylated . Human serum albumin is the main protein of human blood plasma, making up around 50% of human plasma proteins .
Key Biological Properties: Albumin is synthesized by hepatocytes in the liver and released into the bloodstream. It has a relatively long half-life, allowing it to perform its functions continuously . Albumin binds to water, cations (such as Ca2+, Na+, and K+), fatty acids, hormones, bilirubin, thyroxine (T4), and pharmaceuticals .
Expression Patterns and Tissue Distribution: Albumin is primarily synthesized in the liver and is found abundantly in blood plasma. It is also present in other body fluids and tissues .
Primary Biological Functions: Albumin plays a crucial role in maintaining the osmotic balance between blood vessels and surrounding tissues, regulating the distribution of water, electrolytes, and other solutes . It also serves as a carrier protein, transporting various substances in the bloodstream .
Role in Immune Responses and Pathogen Recognition: Albumin exhibits antioxidant properties, scavenging free radicals and protecting against oxidative stress. It also plays a role in the immune response by binding and transporting various substances involved in the immune system .
Mechanisms with Other Molecules and Cells: Albumin binds to a wide variety of molecules, including hormones, fatty acids, and drugs, facilitating their transport and delivery to different tissues and organs . It also acts as a blood plasma buffer, maintaining acid-base balance .
Binding Partners and Downstream Signaling Cascades: Albumin interacts with various binding partners, including calcium, thyroxine, cortisol, and testosterone . These interactions help regulate the availability and activity of these molecules in the body .
Control of Expression and Activity: The synthesis of albumin is regulated by hormonal factors such as insulin, cortisol, and growth hormone (GH), while pro-inflammatory mediators like interleukin (IL)-6 and tumor necrosis factor (TNF)-α inhibit its production .
Transcriptional Regulation and Post-Translational Modifications: Albumin is synthesized in the liver and undergoes various post-translational modifications that affect its function and stability .
Biomedical Research: Albumin is widely used in biomedical research due to its ability to bind and transport various substances. It is used as a standard in protein quantification assays and as a stabilizer in biochemical reactions .
Diagnostic Tools: Albumin levels in the blood are used as a diagnostic marker for liver and kidney function, nutritional status, and overall health .
Therapeutic Strategies: Albumin is used therapeutically to treat conditions such as hypoalbuminemia, hypovolemia, and ascites. It is also used in drug delivery systems to enhance the stability and bioavailability of therapeutic agents .
Development to Aging and Disease: Albumin plays a vital role throughout the life cycle, from development to aging. It helps maintain fluid balance, transport essential molecules, and protect against oxidative stress. Changes in albumin levels can indicate various health conditions, including liver and kidney disease, malnutrition, and inflammation .
