Recombinant Proteins
Product List
EPHA2 Human
EPH Receptor A2 Human Recombinant
EPHA2 Human, sf9
EPH Receptor A2 Human Recombinant, sf9
EPHA2 is fused to 6 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
EPHA3 Mouse
EPH Receptor A3 Mouse Recombinant
EPHA3 Mouse Recombinant produced in HEK293 cells is a single, polypeptide chain containing 527 amino acids (21-541 a.a.) and having a molecular mass of 59.5kDa. EPHA3 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
EPHA4 Mouse
EPH Receptor A4 Mouse Recombinant
(Molecular size on SDS-PAGE will appear at approximately 50-70KDa).
EPHA4 is fused to 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
EPHB1 Human
EPH Receptor B1 Human Recombinant
EPHB1 Human Recombinant produced in HEK293 Cells is a single, glycosylated polypeptide chain containing 529 amino acids (18-540 a.a) and having a molecular mass of 59.2 kDa.
EPHB1 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
EPHB2 Human
EPH Receptor B2 Human Recombinant
EPHB4 Mouse
EPH Receptor B4 Mouse Recombinant
EPHB4 is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Introduction
Eph receptors, named after their expression in an erythropoietin-producing human hepatocellular carcinoma cell line, represent the largest family of receptor tyrosine kinases (RTKs) in the animal kingdom . They are divided into two subclasses, EphA and EphB, based on sequence similarity and their binding affinity for either the glycosylphosphatidylinositol (GPI)-linked ephrin-A ligands or the transmembrane-bound ephrin-B ligands . Humans express nine EphA receptors (EphA1-8 and EphA10) and five EphB receptors (EphB1-4 and EphB6) .
Eph receptors are widely expressed in various tissues and play crucial roles in numerous biological processes. They are involved in cell positioning, tissue patterning, and organ development . Eph receptors are expressed in most, if not all, cell types and are essential for cell contact-dependent communication . Their expression patterns and tissue distribution are highly regulated, with specific receptors being predominant in certain tissues .
Eph receptors are pivotal in regulating cell migration, adhesion, differentiation, and proliferation . They play significant roles in the development of the nervous system, cardiovascular system, and other organs . Eph/ephrin signaling is crucial for immune responses and pathogen recognition, influencing cell-cell communication and immune cell migration .
Eph receptors interact with their ligands, ephrins, on neighboring cells, leading to bidirectional signaling . This interaction can result in either cell-cell adhesion or repulsion, depending on the relative expression and affinity of the ligand-receptor pairs . The signaling cascades initiated by Eph/ephrin interactions involve autophosphorylation of tyrosine residues and recruitment of downstream signaling molecules .
The expression and activity of Eph receptors are tightly regulated at multiple levels. Transcriptional regulation, post-translational modifications, and interactions with other signaling pathways all contribute to the precise control of Eph receptor functions . Proteolytic cleavage and alternative splicing further increase the diversity and complexity of Eph receptor signaling .
Eph receptors have significant applications in biomedical research, diagnostic tools, and therapeutic strategies. They are potential targets for cancer therapy due to their roles in tumor progression, angiogenesis, and metastasis . Eph receptors are also being explored as targets for immunotherapy and as biomarkers for various diseases .
Eph receptors are involved in critical processes throughout the life cycle, from embryonic development to aging . During development, they regulate cell sorting, migration, and boundary formation . In adulthood, Eph receptors maintain tissue homeostasis and are implicated in neural plasticity and immune responses . Dysregulation of Eph signaling is associated with various diseases, including cancer and neurological disorders .
