Recombinant Proteins
Product List
PTX2 Mouse
Pentraxin-2 Mouse Recombinant
PTX2 Mouse Recombinant produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 210 amino acids (21-224 a.a) and having a molecular mass of 24.6kDa. (Molecular size on SDS-PAGE will appear at approximately 28-40kDa). PTX2 is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
PTX3 Human
Pentraxin-3 Human Recombinant
Recombinant Human PTX3 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 401 amino acids (18-381 a.a) and having a molecular mass of 44.4 kDa.
PTX3 is fused to a 37 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.
PTX3 Human, HEK
Pentraxin-3 Human Recombinant, HEK
Introduction
Pentraxin is a family of proteins characterized by a conserved 200 amino acid domain with a distinctive pentameric structure. They are classified into two main groups:
- Short Pentraxins: Includes C-reactive protein (CRP) and serum amyloid P component (SAP).
- Long Pentraxins: Includes pentraxin 3 (PTX3), which has a longer N-terminal domain.
Key Biological Properties:
- Structure: Pentraxins have a cyclic pentameric structure, which is crucial for their function.
- Expression Patterns: Short pentraxins like CRP are primarily produced in the liver, while long pentraxins like PTX3 are produced by a variety of cells including endothelial cells, macrophages, and dendritic cells.
- Tissue Distribution: CRP is found in the blood plasma, whereas PTX3 is found in various tissues, especially at sites of inflammation.
Primary Biological Functions:
- Immune Responses: Pentraxins play a crucial role in the innate immune system by recognizing pathogens and damaged cells.
- Pathogen Recognition: They bind to microbial pathogens and apoptotic cells, facilitating their clearance by immune cells.
Mechanisms with Other Molecules and Cells:
- Binding Partners: Pentraxins interact with complement proteins, Fc receptors, and other pattern recognition receptors.
- Downstream Signaling Cascades: Upon binding to their targets, pentraxins activate complement pathways and enhance phagocytosis by immune cells.
Regulatory Mechanisms:
- Transcriptional Regulation: The expression of pentraxins is regulated by cytokines such as IL-6 and IL-1β, which are released during inflammation.
- Post-Translational Modifications: Glycosylation and phosphorylation are common modifications that affect the stability and function of pentraxins.
Biomedical Research:
- Diagnostic Tools: CRP levels are commonly measured as a marker of inflammation and infection.
- Therapeutic Strategies: PTX3 is being explored as a potential therapeutic target for inflammatory diseases and cancer.
Role Throughout the Life Cycle:
- Development: Pentraxins are involved in the early immune response during development.
- Aging and Disease: Elevated levels of CRP are associated with aging and chronic inflammatory diseases such as cardiovascular disease and rheumatoid arthritis.
