Recombinant Proteins
Product List
GAGE12F Human
G Antigen 12F Human Recombinant
GAGE2A Human
G Antigen 2A Human Recombinant
GAGE2A Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 139 amino acids (1-116) and having a molecular mass of 15.2kDa.
GAGE2A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
GAGE2D Human
G Antigen 2D Human Recombinant
Introduction
Key Biological Properties: The G antigen is a protein found on the surface of red blood cells. It is expressed whenever the D or C antigen is present .
Expression Patterns: The G antigen is expressed in individuals who have either the D or C antigen. This includes the majority of the population, as the D antigen is highly prevalent .
Tissue Distribution: The G antigen is primarily found on red blood cells .
Primary Biological Functions: The G antigen plays a crucial role in the immune response by acting as a target for antibodies. It is involved in the recognition and binding of antibodies, which can lead to the destruction of red blood cells if the antibodies are present .
Role in Immune Responses: The presence of the G antigen can trigger an immune response, particularly in individuals who lack the D and C antigens and are exposed to blood containing these antigens .
Pathogen Recognition: While the G antigen itself is not directly involved in pathogen recognition, its role in the immune response can indirectly affect the body’s ability to recognize and respond to pathogens .
Mechanisms with Other Molecules and Cells: The G antigen interacts with antibodies in the blood. When antibodies bind to the G antigen, it can lead to the destruction of the red blood cells carrying the antigen .
Binding Partners: The primary binding partners for the G antigen are antibodies that recognize the D and C antigens .
Downstream Signaling Cascades: The binding of antibodies to the G antigen can trigger a cascade of immune responses, leading to the destruction of the red blood cells .
Regulatory Mechanisms: The expression of the G antigen is regulated by the presence of the D and C antigens. If either of these antigens is present, the G antigen will also be expressed .
Transcriptional Regulation: The genes responsible for the D and C antigens also regulate the expression of the G antigen .
Post-Translational Modifications: There is limited information on the specific post-translational modifications of the G antigen .
Biomedical Research: The G antigen is studied in the context of blood transfusions and Rh incompatibility. Understanding its role can help improve transfusion practices and prevent adverse reactions .
Diagnostic Tools: The presence of the G antigen can be used to determine Rh compatibility in blood transfusions .
Therapeutic Strategies: In cases of Rh incompatibility, treatments can be developed to prevent the immune response against the G antigen .
Role Throughout the Life Cycle: The G antigen is present from birth and remains throughout an individual’s life. Its role is particularly important in the context of blood transfusions and Rh compatibility .
Development to Aging and Disease: The G antigen does not change significantly with age, but its presence can be critical in certain medical conditions, such as hemolytic disease of the newborn .
