Recombinant Proteins
Product List
CHMP1A Human
Chromatin Modifying Protein 1A Human Recombinant
CHMP1A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CHMP2A Human
Chromatin Modifying Protein 2A Human Recombinant
The CHMP2A is purified by proprietary chromatographic techniques.
CHMP2B Human
Chromatin Modifying Protein 2B Human Recombinant
The CHMP2B is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
CHMP4A Human
Chromatin Modifying Protein 4A Human Recombinant
CHMP4A Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 285 amino acids (1-265) and having a molecular mass of 32.0kDa.
CHMP4A is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
Chromatin modifying proteins are a diverse group of enzymes and proteins that alter the structure and function of chromatin, which is a complex of DNA and proteins found in the nucleus of eukaryotic cells. These modifications can include the addition or removal of chemical groups to histone proteins or DNA, leading to changes in gene expression. Chromatin modifying proteins can be classified into several categories based on their function:
- Writers: Enzymes that add chemical groups to histones or DNA, such as histone acetyltransferases (HATs) and DNA methyltransferases (DNMTs).
- Erasers: Enzymes that remove chemical groups, such as histone deacetylases (HDACs) and demethylases.
- Readers: Proteins that recognize and bind to specific histone or DNA modifications, influencing chromatin structure and gene expression .
Chromatin modifying proteins exhibit key biological properties, including:
- Expression Patterns: These proteins are expressed in a tissue-specific manner, with different types and levels of expression depending on the cell type and developmental stage .
- Tissue Distribution: Chromatin modifying proteins are found in various tissues throughout the body, with some being more prevalent in specific tissues, such as the brain, liver, and immune cells .
The primary biological functions of chromatin modifying proteins include:
- Gene Regulation: They play a crucial role in regulating gene expression by modifying chromatin structure, making it more or less accessible to transcription factors and other regulatory proteins .
- Immune Responses: Chromatin modifying proteins are involved in the regulation of immune responses by modulating the expression of genes related to pathogen recognition and immune cell activation .
- Pathogen Recognition: These proteins help in the recognition of pathogens by altering the expression of genes involved in the immune response .
Chromatin modifying proteins interact with other molecules and cells through various mechanisms:
- Binding Partners: They often form complexes with other proteins, such as transcription factors, to regulate gene expression .
- Downstream Signaling Cascades: Chromatin modifications can trigger downstream signaling cascades that influence cellular processes such as differentiation, proliferation, and apoptosis .
The expression and activity of chromatin modifying proteins are tightly regulated through several mechanisms:
- Transcriptional Regulation: The expression of these proteins is controlled at the transcriptional level by various transcription factors and regulatory elements .
- Post-Translational Modifications: Chromatin modifying proteins themselves can be modified post-translationally, affecting their activity, stability, and interactions with other proteins .
Chromatin modifying proteins have several applications in biomedical research and clinical settings:
- Biomedical Research: They are used to study gene regulation, epigenetics, and the mechanisms underlying various diseases .
- Diagnostic Tools: Chromatin modifications can serve as biomarkers for the diagnosis of diseases such as cancer .
- Therapeutic Strategies: Targeting chromatin modifying proteins with small molecules or other therapeutic agents is a promising strategy for treating diseases, including cancer and neurodegenerative disorders .
Chromatin modifying proteins play essential roles throughout the life cycle, from development to aging and disease:
- Development: They are crucial for proper development by regulating the expression of genes involved in cell differentiation and organogenesis .
- Aging: Changes in chromatin modifications are associated with aging and age-related diseases .
- Disease: Dysregulation of chromatin modifying proteins can lead to various diseases, including cancer, neurodegenerative disorders, and immune-related conditions .
