Recombinant Proteins
Product List
PDCD1 Human
Programmed Cell Death 1 Human Recombinant
PDCD1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 392 amino acids (21-170a.a.) and having a molecular mass of 44.0kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).
PDCD1 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
PDCD1 Human, Active
Programmed Cell Death 1 Human Recombinant, Active
PDCD1 Human Recombinant produced in HEK293 Cells is a single, glycosylated polypeptide chain containing 383 amino acids (21-170 a.a) and having a molecular mass of 42.9kDa.
PDCD1 is fused to a 233 amino acid hIgG-His-Tag at C-terminus & purified by proprietary chromatographic techniques.
PDCD1LG2 Human
Programmed Cell Death 1 Ligand 2 Human Recombinant
PDCD1LG2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
PDCD1LG2 Human, Sf9
Programmed Cell Death 1 Ligand 2 Human Recombinant, Sf9
PDCD1LG2 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 423 amino acids (20-200a.a.) and having a molecular mass of 47.7kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa).
PDCD1LG2 is expressed with a 239 amino acids hIgG-His tag at C-Terminus and purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
PDCD4 Human
Programmed Cell Death 4 Human Recombinant
PDCD5 Human
Programmed Cell Death-5 Human Recombinant
PDCD6 Human
Programmed Cell Death 6 Human Recombinant
PDCD6 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
PDCD6IP Human
Programmed Cell Death 6 Interacting Protein Human Recombinant
Introduction
Programmed Cell Death (PCD) refers to the regulated process by which cells undergo self-destruction in a controlled manner. This process is essential for maintaining homeostasis and proper development in multicellular organisms. PCD can be classified into several types, including:
- Apoptosis: Often termed as cellular suicide, it involves a series of biochemical events leading to characteristic cell changes and death .
- Autophagy: This involves the degradation of cellular components through the lysosomal machinery .
- Necroptosis: A form of programmed necrosis that serves as a backup to apoptosis when the latter is inhibited .
Primary Biological Functions:
- Development: PCD is vital for proper tissue and organ development, such as the formation of separate digits in embryos .
- Immune Responses: PCD helps in eliminating infected or damaged cells, thus preventing the spread of pathogens .
- Pathogen Recognition: Cells undergoing PCD can release signals that alert the immune system to the presence of pathogens .
Mechanisms:
- Intrinsic Pathway: Triggered by internal stimuli like DNA damage, leading to the activation of pro-apoptotic proteins .
- Extrinsic Pathway: Initiated by external signals binding to death receptors on the cell surface .
- Binding Partners: Proteins like Bcl-2 and Bax regulate the susceptibility of cells to apoptosis .
- Downstream Signaling Cascades: Activation of caspases, which are proteases that degrade cellular components .
Control of Expression and Activity:
Throughout the Life Cycle:
