Recombinant Proteins
Product List
RGS1 Human
Regulator of G-Protein Signaling 1 Human Recombinant
RGS1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
RGS10 Human
Regulator of G-Protein Signaling 10 Human Recombinant
The RGS10 is fused to a 24 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
RGS14 Human
Regulator of G-Protein Signaling 14 Human Recombinant
RGS14 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
RGS16 Human
Regulator of G-Protein Signaling 16 Human Recombinant
RGS16 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 222 amino acids (1-202 a.a.) and having a molecular mass of 24.9 kDa. The RGS16 is fused to a 20 amino acid His Tag at N-terminal and purified by proprietary chromatographic techniques.
RGS17 Human
Regulator of G-Protein Signaling 17 Human Recombinant
The RGS17 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
RGS19 Human
Regulator of G-Protein Signaling 19 Human Recombinant
RGS19 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 237 amino acids (1-217a.a.) and having a molecular mass of 26.7kDa.
RGS19 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
RGS2 Human
Regulator of G-Protein Signaling 2 Human Recombinant
RGS2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Sterile filtered colorless solution.
RGS21 Human
Regulator of G-Protein Signaling 21 Human Recombinant
RGS21 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 176 amino acids (1-152 a.a.) and having a molecular mass of 20.2kDa.
RGS21 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
RGS4 Human
Regulator of G-Protein Signaling 4 Human Recombinant
RGS4 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
RGS5 Human
Regulator of G-Protein Signaling 5 Human Recombinant
RGS5 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
Regulators of G-Protein Signaling (RGS) are protein structural domains or proteins containing these domains that function to activate the GTPase activity of heterotrimeric G-protein α-subunits . RGS proteins are multi-functional, GTPase-accelerating proteins that promote GTP hydrolysis by the α-subunit of heterotrimeric G proteins, thereby inactivating the G protein and rapidly switching off G protein-coupled receptor (GPCR) signaling pathways . RGS proteins have been conserved throughout evolution and are classified into several subfamilies based on their structural domains and functions .
Key Biological Properties: RGS proteins are characterized by their ability to accelerate GTP hydrolysis, thus inactivating G proteins . They contain an RGS-box (or RGS domain), which is essential for their activity .
Expression Patterns and Tissue Distribution: RGS proteins are expressed in various tissues and cells, including the brain, heart, and immune cells . Their expression patterns can vary significantly, with some RGS proteins being ubiquitously expressed while others are tissue-specific .
Primary Biological Functions: The primary function of RGS proteins is to regulate GPCR signaling by accelerating the GTPase activity of Gα subunits . This leads to the termination of GPCR downstream signaling pathways .
Role in Immune Responses and Pathogen Recognition: RGS proteins play crucial roles in immune responses by modulating the signaling pathways involved in immune cell activation and migration . They are also involved in pathogen recognition and the regulation of inflammatory responses .
Mechanisms with Other Molecules and Cells: RGS proteins interact with Gα subunits of heterotrimeric G proteins, promoting GTP hydrolysis and inactivating the G protein . This interaction is critical for the regulation of GPCR signaling .
Binding Partners and Downstream Signaling Cascades: RGS proteins can bind to various Gα subunits, and their activity is modulated by other proteins and post-translational modifications . They influence downstream signaling cascades by terminating GPCR signaling .
Regulatory Mechanisms Controlling Expression and Activity: The expression and activity of RGS proteins are regulated at multiple levels, including transcriptional regulation and post-translational modifications . Transcription factors and signaling pathways can modulate the expression of RGS genes .
Transcriptional Regulation and Post-Translational Modifications: RGS proteins undergo various post-translational modifications, such as phosphorylation and ubiquitination, which can affect their stability and activity . These modifications play a crucial role in fine-tuning the activity of RGS proteins in response to cellular signals .
Biomedical Research: RGS proteins are valuable tools in biomedical research for studying GPCR signaling and its regulation . They are used to investigate the mechanisms of various diseases and to identify potential therapeutic targets .
Diagnostic Tools and Therapeutic Strategies: RGS proteins have potential applications in diagnostics and therapeutics. They can serve as biomarkers for certain diseases and as targets for drug development . Modulating the activity of RGS proteins could provide new therapeutic strategies for treating diseases associated with dysregulated GPCR signaling .
Role Throughout the Life Cycle: RGS proteins play essential roles throughout the life cycle, from development to aging and disease . During development, they regulate cell signaling pathways that control cell proliferation, differentiation, and migration . In aging and disease, dysregulation of RGS protein activity can contribute to various pathological conditions, including cancer and neurodegenerative diseases .
