Recombinant Proteins
Product List
TGFBI Human
Transforming Growth Factor Beta Induced Human Recombinant
TGFBI Human Recombinant produced in e.Coli is a single, non-glycosylated, polypeptide containing 135 amino acids (502-636) and having a molecular mass of 14.5 kDa.
The TGFBI recombinant Human protein is purified by proprietary chromatographic techniques.
TGFBI Human, 182 a.a.
Transforming Growth Factor Beta-Induced (182 a.a.) Human Recombinant
The TGFBI recombinant Human protein is purified by proprietary chromatographic techniques.
TGFBRAP1 Human
Transforming Growth Factor Beta Receptor Associated Protein 1 Human Recombinant
TGIF2LX Human
TGFB-Induced Factor Homeobox 2-Like, X-Linked Human Recombinant
TGIF2LX is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
TGIF2LY Human
TGFB-Induced Factor Homeobox 2-Like Y-Linked Human Recombinant
Introduction
Transforming Growth Factor Beta Induced (TGFBI), also known as βig-H3, is an extracellular matrix protein induced by Transforming Growth Factor Beta (TGF-β). TGFBI is part of the TGF-β superfamily, which includes various cytokines involved in cellular processes such as proliferation, differentiation, and apoptosis .
Key Biological Properties: TGFBI is a multifunctional protein that plays a role in cell adhesion, migration, and differentiation. It is involved in various physiological and pathological processes, including wound healing, fibrosis, and cancer .
Expression Patterns: TGFBI is expressed in a wide range of tissues, including the cornea, skin, and various internal organs. Its expression is regulated by TGF-β and other cytokines .
Tissue Distribution: TGFBI is found in the extracellular matrix of many tissues, where it interacts with other matrix proteins and cell surface receptors to mediate its effects .
Primary Biological Functions: TGFBI plays a crucial role in maintaining tissue homeostasis by regulating cell adhesion, migration, and differentiation. It is also involved in the formation of the extracellular matrix and tissue remodeling .
Role in Immune Responses: TGFBI modulates immune responses by influencing the activity of various immune cells, including macrophages and T cells. It can act as both an immune suppressor and an immune activator, depending on the context .
Pathogen Recognition: TGFBI has been shown to play a role in pathogen recognition by binding to microbial components and facilitating their clearance by immune cells .
Mechanisms with Other Molecules and Cells: TGFBI interacts with various cell surface receptors, including integrins and TGF-β receptors, to mediate its effects. These interactions trigger downstream signaling cascades that regulate cellular responses .
Binding Partners: TGFBI binds to several extracellular matrix proteins, such as collagen and fibronectin, as well as cell surface receptors like integrins .
Downstream Signaling Cascades: Upon binding to its receptors, TGFBI activates multiple signaling pathways, including the Smad and MAPK pathways, which regulate gene expression and cellular functions .
Expression and Activity Control: The expression of TGFBI is tightly regulated by TGF-β and other cytokines. Transcriptional regulation involves various transcription factors, including Smad proteins .
Transcriptional Regulation: TGFBI gene expression is controlled by TGF-β signaling through the activation of Smad2/3 transcription factors, which bind to the promoter region of the TGFBI gene .
Post-Translational Modifications: TGFBI undergoes several post-translational modifications, including phosphorylation and glycosylation, which are essential for its stability and function .
Biomedical Research: TGFBI is a valuable target in biomedical research due to its involvement in various diseases, including cancer, fibrosis, and corneal dystrophies .
Diagnostic Tools: TGFBI levels can serve as biomarkers for certain diseases, such as cancer and fibrosis, aiding in diagnosis and prognosis .
Therapeutic Strategies: Targeting TGFBI and its signaling pathways holds potential for developing new therapeutic strategies for diseases like cancer, fibrosis, and inflammatory disorders .
Development: TGFBI plays a critical role in embryonic development by regulating cell differentiation and tissue formation .
Aging: During aging, TGFBI expression and function may be altered, contributing to age-related tissue degeneration and diseases .
Disease: Dysregulation of TGFBI is associated with various diseases, including cancer, fibrosis, and corneal dystrophies. It can act as both a tumor suppressor and a tumor promoter, depending on the context .
