TGIF2LY Human

TGFB-Induced Factor Homeobox 2-Like Y-Linked Human Recombinant
Cat. No.
BT16130
Source
Escherichia Coli.
Synonyms
TGIFLY, Homeobox protein TGIF2LY, TGF-beta-induced transcription factor 2-like protein, TGFB-induced factor 2-like protein, Y-linked, TGIF-like on the Y, TGIF2LY.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 95% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

TGIF2LY Human Recombinant produced in E. coli is. a single polypeptide chain containing 208 amino acids (1-185) and having a molecular mass of 23.2kDa. TGIF2LY is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
TGFB-Induced Factor Homeobox 2-Like Y-Linked (TGIF2LY), a member of the TALE/TGIF homeobox transcription factor family, resides in the male-specific region of the Y chromosome within a sequence block resulting from a large X-to-Y transposition. Functioning as a regulator of TGIF2LX, TGIF2LY's distinct C-terminus from its X chromosome homolog (TGIF2LX) contributes to its regulatory role. Furthermore, TGIF2LY plays a transcriptional role in testis development.
Description
Recombinant human TGIF2LY, expressed in E. coli, is a single polypeptide chain comprising 208 amino acids (1-185) with a molecular weight of 23.2 kDa. The protein includes a 23 amino acid His-tag at the N-terminus and is purified using proprietary chromatographic techniques.
Physical Appearance
A clear, sterile-filtered solution.
Formulation
The TGIF2LY solution is provided at a concentration of 1 mg/ml in a buffer containing 20mM Tris-HCl (pH 8.0), 0.15M NaCl, 10% glycerol, and 1mM DTT.
Stability
For short-term storage (2-4 weeks), keep at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
Purity exceeds 95% as determined by SDS-PAGE analysis.
Synonyms
TGIFLY, Homeobox protein TGIF2LY, TGF-beta-induced transcription factor 2-like protein, TGFB-induced factor 2-like protein, Y-linked, TGIF-like on the Y, TGIF2LY.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMEAAADG PAETQSPVEK DSPAKTQSPA QDTSIMSRNN ADTGRVLALP EHKKKRKGNL PAESVKILRD WMYKHRFKAY PSEEEKQMLS EKTNLSLLRI SNWFINARRR ILPDMLQQRR NDPIIGHKTG KDAHATHLQS TEASVPAKSG PVVQTMYKAC PCGPCQRARC QERSNQIRSR PLARSSPE.

Product Science Overview

Introduction

TGFB-Induced Factor Homeobox 2-Like Y-Linked (TGIF2LY) is a protein-coding gene that belongs to the TALE/TGIF homeobox family of transcription factors. This gene is located within the male-specific region of the Y chromosome, which is thought to have resulted from a large X-to-Y transposition .

Gene and Protein Structure

The TGIF2LY gene encodes a protein that is divergent at its C-terminus from its chromosome X homolog, TGIF2LX. This divergence suggests that TGIF2LY may act as a regulator of TGIF2LX . The protein encoded by TGIF2LY is involved in transcription regulation and may have a specific role in the testis .

Function and Significance

TGIF2LY is believed to play a role in transcription regulation, particularly in the testis. It may act as a competitor or regulator of TGIF2LX, influencing various biological processes . The gene is associated with certain diseases, such as Autosomal Recessive Pyridoxine-Refractory Sideroblastic Anemia 2 .

Recombinant Form

The human recombinant form of TGIF2LY is produced using recombinant DNA technology, which involves inserting the TGIF2LY gene into a suitable expression system to produce the protein in vitro. This recombinant protein can be used for various research and therapeutic purposes, including studying its function and potential role in diseases.

Research and Applications

Research on TGIF2LY has shown its involvement in various cellular processes. For example, phosphorylation of TGIF2 has been identified as a therapeutic target in lung adenocarcinoma, where it drives epithelial-mesenchymal transition (EMT) and metastasis . This highlights the potential of TGIF2LY as a target for cancer therapy.

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