Recombinant Proteins
Product List
CRIP1 Human
Cysteine-Rich Protein 1 Human Recombinant
CRIPT Human
Cysteine-Rich PDZ-Binding Protein Human Recombinant
CRIPT is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
Cysteine-rich proteins (CRPs) are small proteins characterized by a high content of cysteine residues. These cysteines can form disulfide bonds or bind metal ions, stabilizing the protein’s tertiary structure . CRPs are classified based on their structural motifs and functions, including defensins, metallothioneins, and lipid transfer proteins .
Key Biological Properties: CRPs exhibit diverse biological properties, including antimicrobial activity, metal ion binding, and redox regulation . They are crucial for maintaining cellular homeostasis and protecting against oxidative stress .
Expression Patterns and Tissue Distribution: CRPs are widely expressed across various tissues and organisms. In plants, they are abundant in reproductive tissues and play roles in pollen tube growth and seed development . In animals, they are found in skin, hair, and nails, contributing to structural integrity and defense mechanisms .
Primary Biological Functions: CRPs are involved in numerous biological processes, including immune responses, pathogen recognition, and cellular signaling . They act as antimicrobial peptides, protecting against bacterial, fungal, and viral infections .
Role in Immune Responses and Pathogen Recognition: CRPs, such as defensins, play a critical role in the innate immune system by directly targeting and neutralizing pathogens . They also modulate immune cell activity and enhance pathogen clearance .
Mechanisms with Other Molecules and Cells: CRPs interact with various molecules and cells through binding to specific receptors or forming complexes with metal ions . These interactions trigger downstream signaling cascades that regulate cellular responses .
Binding Partners and Downstream Signaling Cascades: CRPs bind to receptors on the cell surface, initiating signaling pathways that lead to changes in gene expression and cellular behavior . For example, defensins bind to microbial membranes, causing membrane disruption and pathogen death .
Regulatory Mechanisms Controlling Expression and Activity: The expression and activity of CRPs are tightly regulated at multiple levels, including transcriptional regulation and post-translational modifications . Transcription factors and signaling molecules modulate CRP gene expression in response to environmental cues .
Transcriptional Regulation and Post-Translational Modifications: CRP genes are regulated by transcription factors that respond to stress signals, ensuring timely expression . Post-translational modifications, such as phosphorylation and glycosylation, further modulate CRP activity and stability .
Biomedical Research: CRPs are valuable tools in biomedical research for studying immune responses, cell signaling, and disease mechanisms . They serve as models for understanding protein folding and stability .
Diagnostic Tools and Therapeutic Strategies: CRPs have potential applications in diagnostics and therapeutics. They can be used as biomarkers for disease detection and as therapeutic agents for treating infections and inflammatory conditions .
Role Throughout the Life Cycle: CRPs play essential roles throughout the life cycle, from development to aging and disease . During development, they regulate processes such as cell differentiation and tissue patterning . In aging, CRPs help maintain cellular homeostasis and protect against oxidative damage .
From Development to Aging and Disease: CRPs are involved in various stages of life, contributing to growth, reproduction, and defense mechanisms . Their dysregulation is associated with diseases such as cancer, neurodegenerative disorders, and immune deficiencies .
