Recombinant Proteins
Product List
CDC123 Human
Cell Division Cycle 123 Human Recombinant
CDC25A Human
Cell Division Cycle 25A Human Recombinant
CDC26 Human
Cell Division Cycle 26 Human Recombinant
CDC26 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CDC34 Human
Cell Division Cycle 34 Human Recombinant
Cell Division Cycle 34 Human Recombinant produced in E.Coli is a single, non- glycosylated polypeptide chain containing 236 amino acids and having a molecular mass of 26.7kDa.
CDC34 is purified by proprietary chromatographic techniques.
Escherichia Coli.
CDC34 Human, His
Cell Division Cycle 34 Human Recombinant, His Tag
CDC34 Human Recombinant protein fused to a 20 amino acid N-terminal His-Tag produced in E.Coli is a single, non-glycosylated polypeptide chain containing 256 amino acids (1-236 a.a.) and having a molecular mass of 28.9 kDa. CDC34 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CDC37 Human
Cell Division Cycle 37 Human Recombinant
CDC37 Human, His
Cell Division Cycle 37 Human Recombinant, His Tag
N-Terminal His-tag.
CDC42 Human
Cell Division Cycle 42 Human Recombinant
The CDC42 is purified by proprietary chromatographic techniques.
Introduction
The cell division cycle, also known as the cell cycle, is a series of events that cells go through to grow, replicate their DNA, and divide into two daughter cells. This process is essential for growth, development, and tissue repair in multicellular organisms, as well as for reproduction in unicellular organisms .
The cell cycle is classified into two main types based on the type of cell division:
- Mitosis: This type of cell division results in two genetically identical daughter cells and is used for growth, tissue repair, and asexual reproduction in eukaryotic organisms .
- Meiosis: This type of cell division results in four genetically diverse daughter cells with half the number of chromosomes of the parent cell. It is used for sexual reproduction in eukaryotic organisms .
The cell cycle is characterized by several key biological properties:
- Expression Patterns: The cell cycle is regulated by the expression of various cyclins and cyclin-dependent kinases (CDKs) that control the progression through different phases .
- Tissue Distribution: The cell cycle occurs in all proliferating cells, including stem cells, somatic cells, and germ cells. However, the rate of cell division varies among different tissues. For example, cells in the bone marrow and gastrointestinal tract divide rapidly, while neurons and muscle cells divide infrequently .
The primary biological functions of the cell cycle include:
- Growth and Development: The cell cycle is essential for the growth and development of multicellular organisms, allowing them to increase in size and complexity .
- Tissue Repair: The cell cycle enables the replacement of damaged or dead cells, maintaining tissue integrity and function .
- Immune Responses and Pathogen Recognition: The cell cycle plays a role in the proliferation of immune cells, such as lymphocytes, which are crucial for mounting an effective immune response and recognizing pathogens .
The cell cycle involves several mechanisms and interactions with other molecules and cells:
- Binding Partners: Cyclins bind to CDKs, forming active complexes that phosphorylate target proteins to drive the cell cycle forward .
- Downstream Signaling Cascades: The activation of cyclin-CDK complexes triggers downstream signaling cascades that regulate DNA replication, chromosome segregation, and cytokinesis .
The cell cycle is tightly regulated by various mechanisms to ensure accurate and timely cell division:
- Transcriptional Regulation: The expression of cyclins and CDKs is regulated at the transcriptional level by transcription factors and other regulatory proteins .
- Post-Translational Modifications: Cyclins and CDKs undergo post-translational modifications, such as phosphorylation and ubiquitination, which modulate their activity and stability .
- Checkpoints: The cell cycle has several checkpoints, such as the G1/S checkpoint and the G2/M checkpoint, that monitor the integrity of the DNA and ensure that the cell is ready to proceed to the next phase .
The study of the cell cycle has numerous applications in biomedical research, diagnostics, and therapeutics:
- Cancer Research: Understanding the cell cycle is crucial for cancer research, as dysregulation of the cell cycle is a hallmark of cancer. Targeting cell cycle regulators, such as CDKs, is a promising therapeutic strategy for cancer treatment .
- Stem Cell Research: Insights into the cell cycle are essential for stem cell research, as the ability of stem cells to proliferate and differentiate is tightly linked to cell cycle regulation .
- Diagnostic Tools: Cell cycle markers, such as Ki-67, are used as diagnostic tools to assess cell proliferation in various diseases, including cancer .
The cell cycle plays a vital role throughout the life cycle of an organism:
- Development: During embryonic development, rapid cell division is necessary for the formation of tissues and organs .
- Aging: As organisms age, the regulation of the cell cycle becomes less efficient, leading to a decline in tissue regeneration and an increase in the risk of diseases, such as cancer .
- Disease: Dysregulation of the cell cycle can lead to various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases .
