Recombinant Proteins
Product List
CEA Human
Carcinoembryonic Antigen Human Recombinant
CEA Human, His
Carcinoembryonic Antigen Human Recombinant, His Tag
CEA Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 659 amino acids (35-685a.a.) and having a molecular mass of 72.3kDa (Molecular size on SDS-PAGE will appear at approximately 70-150kDa). CEA is expressed with an 8 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
CEACAM1 Human
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Human Recombinant
CEACAM1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 405 amino acids (35-428 a.a.) and having a molecular mass of 44.6kDa (Molecular size on SDS-PAGE will appear at approximately 40-70 kDa). CEACAM1 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
CEACAM21 Human
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 21 Human Recombinant
CEACAM3 Human
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3 Human Recombinant
CEACAM3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CEACAM3 Human, Sf9
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3 Human Recombinant, Sf9
CEACAM3 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 130 amino acids (35-155a.a.) and having a molecular mass of 14.2kDa (Molecular size on SDS-PAGE will appear at approximately 13.5-18kDa).
CEACAM3 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
CEACAM6 Human
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 Recombinant Human
CEACAM6 is fused to 6 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
CEACAM7 Human
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7 Human Recombinant
CEACAM7 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
CEACAM8 Human
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 8 Human Recombinant
CEACAM8 Human produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 292 amino acids (35-320 a.a) and having a molecular mass of 32.3kDa.
CEACAM8 is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
Sterile filtered colorless solution.
Introduction
Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion. It is part of a family of related glycoproteins known as the carcinoembryonic antigen-related cell adhesion molecules (CEACAMs). CEA is primarily used as a tumor marker in clinical settings to monitor the treatment and progression of certain cancers, particularly colorectal cancer .
CEA is a glycoprotein with a molecular weight of approximately 150-180 kDa. It is composed of a protein core and multiple carbohydrate chains. CEA is normally produced in gastrointestinal tissue during fetal development, but its production ceases before birth. In healthy adults, CEA levels are typically very low (about 2-4 ng/mL) . However, elevated levels can be found in certain cancers and non-cancerous conditions .
CEA interacts with other molecules and cells through its glycosyl phosphatidyl inositol (GPI) anchor, which attaches it to the cell membrane. This interaction facilitates cell-cell adhesion and signaling. CEA can bind to other CEACAM family members and participate in homotypic binding, which is essential for its role in cell adhesion .
The expression and activity of CEA are regulated at multiple levels, including transcriptional regulation and post-translational modifications. The CEA gene family includes a promoter region that confers cell type-specific expression. Post-translational modifications, such as glycosylation, are crucial for the proper functioning of CEA .
CEA is widely used in biomedical research and clinical diagnostics. It serves as a tumor marker for monitoring the treatment and progression of cancers, particularly colorectal cancer. CEA levels are measured in blood tests to assess the effectiveness of cancer treatments and to detect recurrences . Additionally, CEA is being explored as a target for therapeutic strategies, including immunotherapy .
CEA plays a significant role throughout the life cycle, from development to aging and disease. During fetal development, CEA is produced in gastrointestinal tissue. In adults, its levels are typically low but can increase in response to certain cancers and inflammatory conditions. Monitoring CEA levels can provide valuable insights into the progression of diseases and the effectiveness of treatments .
