CEACAM3 Human, Sf9
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3, Carcinoembryonic Antigen CGM1, CD66d Antigen , CD66D, CGM1, Carcinoembryonic Antigen Gene Family Member 1, Nonspecific Cross-Reacting Antigen, W264, W282, CEA, CEACAM3.
Greater than 95.0% as determined by SDS-PAGE.
Description
CEACAM3 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 130 amino acids (35-155a.a.) and having a molecular mass of 14.2kDa (Molecular size on SDS-PAGE will appear at approximately 13.5-18kDa).
CEACAM3 is expressed with a 6 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Specs
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3, Carcinoembryonic Antigen CGM1, CD66d Antigen , CD66D, CGM1, Carcinoembryonic Antigen Gene Family Member 1, Nonspecific Cross-Reacting Antigen, W264, W282, CEA, CEACAM3.
ADPKLTIESM PLSVAEGKEV LLLVHNLPQH LFGYSWYKGE RVDGNSLIVG YVIGTQQATP GAAYSGRETI YTNASLLIQN VTQNDIGFYT LQVIKSDLVN EEATGQFHVY QENAPGLPVG AVAGHHHHHH.
Product Science Overview
CEACAM3 was initially identified as a granulocyte-specific receptor that plays a crucial role in the immune system. It is characterized by its extracellular immunoglobulin (Ig) variable (V)-like domain, which enables both homophilic interactions (binding to itself) and heterophilic interactions (binding to other CEACAM molecules) . This domain structure is essential for its function in mediating cell adhesion and immune responses.
CEACAM3 is primarily expressed on granulocytes, a type of white blood cell involved in the body’s defense against bacterial infections. It functions as a decoy receptor for CEACAM1, another member of the CEA family, and mediates the uptake and destruction of specific bacterial pathogens via its immunoreceptor tyrosine-based activation motif (ITAM)-like motif . This process is crucial for the immune system’s ability to recognize and eliminate bacterial invaders.
CEACAM3, along with other CEACAM family members, has been studied extensively for its role in cancer progression and metastasis. The expression of CEACAM molecules can be modulated by various factors, including bacterial and viral infections, as well as inflammatory cytokines . This modulation can influence the behavior of cancer cells, making CEACAM3 a potential target for therapeutic interventions in cancer treatment .
The recombinant form of CEACAM3, produced in Sf9 insect cells, is used for research and therapeutic purposes. Sf9 cells, derived from the fall armyworm (Spodoptera frugiperda), are commonly used in biotechnology for the production of recombinant proteins. These cells are advantageous for producing glycoproteins like CEACAM3 because they can perform post-translational modifications similar to those in mammalian cells.
Recombinant CEACAM3 is utilized in various research applications, including studies on cell adhesion, immune responses, and cancer biology. It serves as a valuable tool for understanding the molecular mechanisms underlying these processes and for developing potential therapeutic strategies.
