Recombinant Proteins
Product List
LTF Apo Human
Lactoferrin Apo Human Recombinant
Recombinant Human Apo Lactoferrin produced in Plant is a glycosylated mature polypeptide sequence having an approximate molecular mass of 80 kDa.
The Human Apo Lactoferrin is purified by proprietary chromatographic techniques.
LTF Holo Human
Lactoferrin Holo Human Recombinant
Recombinant Human Holo Lactoferrin produced in Plant is a glycosylated mature polypeptide sequence having an approximate molecular mass of 80 kDa.
The Human Holo Lactoferrin is purified by proprietary chromatographic techniques.
LTF Human
Lactoferrin Human (Breast Milk)
LTF Human S.Plasma
Lactoferrin Human (Seminal Plasma)
Introduction
Lactoferrin (LF), also known as lactotransferrin (LTF), is a multifunctional glycoprotein belonging to the transferrin family . It is a globular protein with a molecular mass of approximately 80 kDa and is widely present in various secretory fluids such as milk, saliva, tears, and nasal secretions . Lactoferrin is also found in the secondary granules of neutrophils and is secreted by some acinar cells .
Lactoferrin exhibits several key biological properties, including its ability to bind and transport iron ions, which is crucial for its antimicrobial activity . It has antibacterial, antiviral, antiparasitic, catalytic, anti-cancer, and anti-allergic functions . Lactoferrin is expressed in various tissues, including the mammary glands, salivary glands, and mucosal surfaces . It is constantly produced and released into saliva, tears, and other bodily fluids .
Lactoferrin plays a significant role in the immune system. It is involved in the regulation of iron homeostasis, which is essential for limiting the availability of iron to pathogens, thereby inhibiting their growth . Lactoferrin also has direct antimicrobial properties, including bactericidal and fungicidal activities . Additionally, it modulates immune responses by interacting with various immune cells and influencing their functions . Lactoferrin is involved in pathogen recognition and can bind to bacterial lipopolysaccharides, preventing bacterial adhesion and invasion .
Lactoferrin exerts its effects through multiple mechanisms. It binds to iron with high affinity, depriving pathogens of the iron necessary for their growth . Lactoferrin also interacts with various receptors on the surface of immune cells, such as monocytes, macrophages, and lymphocytes, modulating their activity . It can inhibit the entry of viruses into host cells by binding to viral receptors . Lactoferrin also interacts with DNA, RNA, polysaccharides, and heparin, forming complexes that contribute to its biological functions .
The expression and activity of lactoferrin are regulated by various mechanisms. Transcriptional regulation of lactoferrin is influenced by factors such as estrogen, retinoic acid, mitogens, and growth factors . Post-translational modifications, including glycosylation, also play a role in modulating lactoferrin’s activity . These regulatory mechanisms ensure that lactoferrin is produced and functions appropriately in response to physiological needs and environmental stimuli .
Lactoferrin has numerous applications in biomedical research, diagnostics, and therapeutics. It is used as a biomarker for various diseases and conditions due to its presence in bodily fluids . Lactoferrin’s antimicrobial and anti-inflammatory properties make it a potential therapeutic agent for treating infections and inflammatory diseases . It is also explored for its role in cancer therapy, as it can inhibit tumor growth and metastasis . Additionally, lactoferrin is used in dietary supplements to support immune function and overall health .
Lactoferrin plays a crucial role throughout the life cycle, from development to aging and disease. In infants, lactoferrin in colostrum and breast milk provides essential immune protection and supports gut health . During adulthood, lactoferrin continues to contribute to immune defense and iron homeostasis . In aging individuals, lactoferrin’s antioxidant and anti-inflammatory properties may help mitigate age-related diseases and support overall health . Lactoferrin’s role in cancer prevention and therapy further underscores its importance in maintaining health throughout life .
