Recombinant Proteins
Product List
NAP1L1 Human
Nucleosome Assembly Protein 1-Like 1 Human Recombinant
NAP1L1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
NAP1L4 Human
Nucleosome Assembly Protein 1-Like 4 Human Recombinant
NAP1L4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
Nucleosome Assembly Proteins (NAPs) are histone chaperones that play a crucial role in the assembly and disassembly of nucleosomes, which are the fundamental units of chromatin. Nucleosomes consist of DNA wrapped around histone proteins, and their proper assembly is essential for DNA packaging and regulation within the cell . NAPs are classified into various families based on their structure and function, with the NAP1 family being one of the most well-studied .
NAPs exhibit several key biological properties:
- Expression Patterns: NAPs are ubiquitously expressed in eukaryotic cells, with varying levels depending on the cell type and developmental stage .
- Tissue Distribution: These proteins are found in all tissues, but their expression levels can be particularly high in rapidly dividing cells, such as those in the immune system and during embryonic development .
NAPs serve several primary biological functions:
- Gene Regulation: By facilitating the proper assembly of nucleosomes, NAPs play a critical role in regulating gene expression .
- Immune Responses: NAPs are involved in the regulation of genes that are crucial for immune responses and pathogen recognition .
- Chromatin Dynamics: They help maintain chromatin structure during DNA replication, repair, and transcription .
NAPs interact with other molecules and cells through various mechanisms:
The expression and activity of NAPs are tightly regulated:
- Transcriptional Regulation: NAPs are regulated at the transcriptional level by various transcription factors and signaling pathways .
- Post-Translational Modifications: NAPs undergo post-translational modifications, such as phosphorylation and acetylation, which modulate their activity and interactions with histones .
NAPs have several applications in biomedical research and therapeutic strategies:
- Diagnostic Tools: NAPs can be used as biomarkers for certain diseases, given their role in gene regulation and chromatin dynamics .
- Therapeutic Strategies: Targeting NAPs and their interactions with histones offers potential therapeutic strategies for diseases involving chromatin dysregulation, such as cancer .
NAPs play a vital role throughout the life cycle:
