Recombinant Proteins
Product List
FGB Human
Fibrinogen Beta Chain Human Recombinant
FGG Human
Fibrinogen Gamma Chain Human Recombinant
FGG is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
FSBP Human
Fibrinogen Silencer Binding Protein Human Recombinant
FSBP is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
Fibrinogen, also known as coagulation factor I, is a glycoprotein complex produced in the liver that circulates in the blood of all vertebrates . It plays a crucial role in blood clotting by being converted enzymatically by thrombin to fibrin, which then forms a fibrin-based blood clot . Fibrinogen is classified as a positive acute-phase protein, meaning its levels increase in response to inflammation, tissue injury, and other systemic events .
Fibrinogen is primarily produced by liver hepatocyte cells and circulates in the blood at concentrations of 2-4 g/L . It is also produced in small amounts by endothelial cells . The protein is composed of three pairs of polypeptide chains: Aα, Bβ, and γ, with molecular masses of 66.2, 54.5, and 48.4 kDa, respectively . Fibrinogen is distributed throughout the bloodstream and is essential for various biological processes, including blood clot formation, wound healing, and inflammation .
Fibrinogen’s primary function is to form fibrin clots that occlude blood vessels to stop bleeding . It also plays a role in immune responses by mediating blood platelet and endothelial cell spreading, tissue fibroblast proliferation, capillary tube formation, and angiogenesis . Additionally, fibrinogen is involved in pathogen recognition and helps in the body’s defense against infections .
Fibrinogen interacts with various molecules and cells through specific binding sites. During tissue and vascular injury, it is converted to fibrin by thrombin, which then forms a mesh that stabilizes blood clots . Fibrinogen also binds to receptors on the surface of platelets, facilitating their aggregation and the formation of a stable blood clot . This interaction is crucial for hemostasis and wound healing .
The expression and activity of fibrinogen are regulated by hormones and cytokines. Glucocorticoids like dexamethasone and interleukin-6 (IL-6) increase fibrinogen biosynthesis, while estrogen and inflammatory cytokines such as IL-4, IL-10, and IL-13 decrease its production . Fibrinogen gene expression is controlled by proximal promoters and local enhancer elements, which respond to acute-phase inflammatory stimuli .
Fibrinogen has several applications in biomedical research, diagnostic tools, and therapeutic strategies. It is used to study blood clotting mechanisms, wound healing, and inflammation . Clinically, fibrinogen levels are measured to diagnose bleeding disorders, thrombotic conditions, and inflammatory diseases . Therapeutically, fibrinogen concentrates are used to treat patients with congenital or acquired fibrinogen deficiencies .
Throughout the life cycle, fibrinogen plays a vital role in maintaining vascular integrity and responding to tissue injury . During development, it is essential for proper blood clot formation and wound healing. In aging and disease, fibrinogen levels can be elevated, contributing to conditions such as cardiovascular disease, stroke, and chronic inflammation . Its role in inflammation and tissue repair makes it a critical factor in both health and disease .
