Recombinant Proteins
Product List
RBM17 Human
RNA Binding Motif Protein 17 Human Recombinant
RBM17 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
RBM18 Human
RNA Binding Motif Protein 18 Human Recombinant
RBM18 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
RBM3 Human
RNA Binding Motif Protein 3 Human Recombinant
RBM8A Human
RNA Binding Motif Protein 8A Human Recombinant
RBM8A is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Introduction
RNA Binding Motif Proteins (RBPs) are a class of proteins that bind to RNA molecules, either double or single-stranded, and participate in forming ribonucleoprotein complexes . These proteins contain various structural motifs such as RNA recognition motif (RRM), dsRNA binding domain, and zinc finger . RBPs are crucial in post-transcriptional regulation of gene expression, including splicing, polyadenylation, mRNA stabilization, localization, and translation .
Key Biological Properties: RBPs have modular structures composed of multiple repeats of specific basic domains . They bind RNA with different sequence specificities and affinities, allowing them to regulate various aspects of RNA metabolism .
Expression Patterns and Tissue Distribution: RBPs are expressed in diverse tissues and cells, with unique RNA-binding activities and protein-protein interactions . Their expression patterns can vary significantly depending on the tissue type and developmental stage .
Primary Biological Functions: RBPs play central roles in RNA processing, including splicing, translation, transport, and degradation . They are involved in the formation of ribonucleoprotein complexes, which are essential for RNA stability and function .
Role in Immune Responses and Pathogen Recognition: RBPs are involved in the regulation of immune responses by modulating the expression of cytokines and other immune-related genes . They also play a role in pathogen recognition by binding to viral RNAs and regulating antiviral responses .
Mechanisms with Other Molecules and Cells: RBPs interact with various molecules, including other proteins and RNAs, to regulate RNA metabolism . They recognize specific RNA sequences and structures, which allows them to bind to their target RNAs with high specificity .
Binding Partners and Downstream Signaling Cascades: RBPs often form complexes with other proteins to exert their functions. These complexes can influence downstream signaling cascades, such as those involved in RNA splicing and translation .
Transcriptional Regulation: The expression of RBPs is tightly regulated at the transcriptional level by various transcription factors and signaling pathways .
Post-Translational Modifications: RBPs undergo post-translational modifications, such as phosphorylation and ubiquitination, which can affect their stability, localization, and activity .
Biomedical Research: RBPs are used as tools to study RNA biology and gene expression regulation .
Diagnostic Tools: RBPs can serve as biomarkers for various diseases, including cancer and cardiovascular diseases .
Therapeutic Strategies: Targeting RBPs with small molecules or RNA-based therapies holds potential for treating diseases associated with dysregulated RNA metabolism .
Development to Aging and Disease: RBPs play crucial roles throughout the life cycle, from development to aging . They are involved in processes such as cell differentiation, proliferation, and apoptosis . Dysregulation of RBPs is associated with various diseases, including neurodegenerative disorders and cancer .
