RBM18 Human

RNA Binding Motif Protein 18 Human Recombinant
Cat. No.
BT18841
Source
Escherichia Coli.
Synonyms
RNA Binding Motif Protein 18, RNA-Binding Motif Protein 18, RBM18.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 85.0% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

RBM18 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 213 amino acids (1-190 a.a) and having a molecular mass of 24kDa.
RBM18 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
RNA Binding Motif Protein 18, also known as RBM18, possesses a single RNA recognition motif (RRM) domain.
Description
Recombinant RBM18 from humans has been produced in E. coli. This protein is a single, non-glycosylated polypeptide chain consisting of 213 amino acids (specifically, amino acids 1 to 190) and possesses a molecular weight of 24 kDa. The RBM18 protein is fused to a 23 amino acid His-tag located at the N-terminus. Purification is achieved through proprietary chromatographic techniques.
Physical Appearance
The product is provided as a clear solution that has been sterilized by filtration.
Formulation
The RBM18 protein is provided in a solution with a concentration of 1 mg/ml. The solution also contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability
For optimal storage, it is recommended to keep the product at 4°C if the entire vial is to be used within 2-4 weeks. For long-term storage, the product should be stored frozen at -20°C. The addition of a carrier protein (0.1% HSA or BSA) is recommended for extended storage durations. It is important to avoid subjecting the product to multiple freeze-thaw cycles.
Purity
Analysis by SDS-PAGE has determined that the purity of the protein is greater than 85%.
Synonyms
RNA Binding Motif Protein 18, RNA-Binding Motif Protein 18, RBM18.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMEAETKT LPLENASILS EGSLQEGHRL WIGNLDPKIT EYHLLKLLQK FGKVKQFDFL FHKSGALEGQ PRGYCFVNFE TKQEAEQAIQ CLNGKLALSK KLVVRWAHAQ VKRYDHNKND KILPISLEPS SSTEPTQSNL SVTAKIKAIE AKLKMMAENP DAEYPAAPVY SYFKPPDKKR TTPYSRTAWK SRR.

Product Science Overview

Structure and Function

RBM18 is a protein coding gene that plays a crucial role in RNA metabolism. It is involved in various processes such as RNA splicing, transport, translation, and stability . The protein is predicted to enable RNA binding activity and is located in the cytosol, intercellular bridge, and nucleoplasm .

Gene Information

The RBM18 gene is located on chromosome 9 in humans. It has several aliases, including probable RNA-binding protein 18 and MGC2734 . The gene ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding .

Biological Significance

RBM18 is essential for the proper functioning of RNA processes within the cell. Its involvement in RNA splicing and other RNA metabolic processes makes it a critical component in the regulation of gene expression . The protein’s ability to bind RNA suggests that it may play a role in the post-transcriptional regulation of gene expression.

Research and Applications

Research on RBM18 has shown its potential implications in various biological processes and diseases. The study of RBM18 and other RNA-binding proteins is crucial for understanding the complex mechanisms of RNA metabolism and its impact on cellular functions . Recombinant forms of RBM18 are used in research to study its structure, function, and interactions with other molecules.

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