Recombinant Proteins
Product List
LY6G6F Human
Lymphocyte Antigen 6 Complex Locus G6F Human Recombinant
LY86 Human
Lymphocyte Antigen 86 Human Recombinant
LY86 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
LY9 Human
Lymphocyte Antigen 9 Human Recombinant
LY9 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Introduction
Lymphocyte antigens are molecules, often proteins, located on the surface of lymphocytes, which are a type of white blood cell. These antigens play a crucial role in the immune system by helping to identify and respond to foreign substances, such as pathogens. Lymphocytes are classified into three main types: B lymphocytes (B cells), T lymphocytes (T cells), and natural killer (NK) cells .
Key Biological Properties: Lymphocyte antigens are highly specific molecules that can bind to particular antigens. They are essential for the immune system’s ability to recognize and respond to pathogens .
Expression Patterns: Lymphocyte antigens are expressed on the surface of lymphocytes. Each lymphocyte produces its own specific receptor that corresponds to a specific antigen .
Tissue Distribution: Lymphocytes are found in various tissues, including the blood, lymph nodes, spleen, thymus, and other lymphoid tissues .
Primary Biological Functions: Lymphocyte antigens are involved in the recognition and binding of foreign substances, leading to the activation of immune responses . B cells produce antibodies, T cells directly attack infected cells, and NK cells destroy damaged or abnormal cells .
Role in Immune Responses: Lymphocyte antigens are critical for both humoral and cell-mediated immunity. They help the immune system remember previous encounters with pathogens, leading to a quicker and more effective response upon re-exposure .
Pathogen Recognition: Lymphocyte antigens detect foreign proteins on pathogens, triggering the production of antibodies and other immune responses .
Mechanisms with Other Molecules and Cells: Lymphocyte antigens interact with other immune cells and molecules to coordinate the immune response. For example, T cells require antigen presentation by other cells to become activated .
Binding Partners: Lymphocyte antigens bind to specific receptors on the surface of pathogens or infected cells .
Downstream Signaling Cascades: Upon binding to their specific antigens, lymphocyte antigens initiate signaling cascades that lead to the activation and proliferation of immune cells .
Control of Expression and Activity: The expression and activity of lymphocyte antigens are tightly regulated by various mechanisms, including transcriptional regulation and post-translational modifications .
Transcriptional Regulation: Genes encoding lymphocyte antigens are regulated at the transcriptional level to ensure appropriate expression in response to immune challenges .
Post-Translational Modifications: Lymphocyte antigens undergo post-translational modifications, such as phosphorylation, to modulate their activity and interactions with other molecules .
Biomedical Research: Lymphocyte antigens are widely studied in biomedical research to understand immune responses and develop new therapies .
Diagnostic Tools: They are used in diagnostic assays to detect immune responses and diagnose infections and autoimmune diseases .
Therapeutic Strategies: Targeting lymphocyte antigens is a promising approach in immunotherapy for treating cancers and autoimmune diseases .
Development: Lymphocyte antigens are essential for the development and maturation of lymphocytes in the bone marrow and thymus .
Aging and Disease: The function of lymphocyte antigens can decline with age, leading to increased susceptibility to infections and diseases . They also play a role in the development of autoimmune diseases and cancers .
