Recombinant Proteins
Product List
IMPAD1 Human
Inositol Monophosphatase Domain Containing 1 Human Recombinant
IMPAD1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
IMPAD1 Human, Active
Inositol Monophosphatase Domain Containing 1 Human Recombinant, BioActive
IMPAD1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 349 amino acids (34-359 a.a.) and having a molecular mass of 37.6kDa.
IMPAD1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Escherichia Coli.
IMPAD1 Mouse
Inositol Monophosphatase Domain Containing 1 Mouse Recombinant
IMPAD1 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
IMPAD1 Mouse Bioactive
Inositol Monophosphatase Domain Containing 1 Mouse Recombinant Bioactive
Introduction
Key Biological Properties: IMPAD1 is part of the inositol monophosphatase superfamily and is involved in crucial cellular processes such as phosphoinositide signaling.
Expression Patterns and Tissue Distribution: IMPAD1 is expressed in various tissues, with notable expression in the brain, cartilage, and other tissues. It has been associated with GRAPP type chondrodysplasia with joint dislocations .
Primary Biological Functions: IMPAD1 plays a significant role in phosphoinositide signaling by hydrolyzing PAP to AMP. This function is crucial for maintaining cellular homeostasis and signaling pathways .
Role in Immune Responses and Pathogen Recognition: While specific roles in immune responses and pathogen recognition are not well-documented, its involvement in cellular signaling suggests potential indirect roles in these processes.
Mechanisms with Other Molecules and Cells: IMPAD1 interacts with various molecules within the Golgi apparatus to regulate phosphoinositide signaling. It is also involved in vesicular trafficking, which is essential for cellular communication and transport .
Binding Partners and Downstream Signaling Cascades: IMPAD1’s activity influences downstream signaling cascades by regulating the levels of inositol phosphates, which are critical for various cellular functions .
Transcriptional Regulation: IMPAD1 expression is regulated at the transcriptional level by various factors, including microRNAs such as miR-200 and miR-96. These microRNAs can repress IMPAD1 expression, and their loss during epithelial-to-mesenchymal transition (EMT) leads to de-repression of IMPAD1 .
Post-Translational Modifications: Post-translational modifications of IMPAD1, such as phosphorylation, may regulate its activity and stability, although specific details are not well-documented .
Biomedical Research: IMPAD1 is a target of interest in cancer research, particularly in understanding its role in metastasis and tumor progression. It has been implicated in lung cancer invasion and metastasis .
Diagnostic Tools and Therapeutic Strategies: Antibodies targeting IMPAD1 are used in various diagnostic applications, including Western Blot, Immunohistochemistry, and ELISA. These tools help in studying IMPAD1 expression and function in different tissues .
