Recombinant Proteins
Product List
REN Human
Renin Human Recombinant
REN Human, HEK
Renin Human Recombinant, HEK
REN Human, sf9
Renin Human Recombinant, sf9
REN is fused to 8 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.
REN Mouse
Renin Mouse Recombinant
Introduction
Renin, also known as angiotensinogenase, is an aspartic protease enzyme secreted by the kidneys. It plays a crucial role in the renin-angiotensin-aldosterone system (RAAS), which regulates blood pressure, fluid, and electrolyte balance . Renin is classified as an enzyme with the EC number 3.4.23.15 .
Key Biological Properties: Renin is an enzyme that catalyzes the conversion of angiotensinogen to angiotensin I, a precursor to angiotensin II, which is a potent vasoconstrictor .
Expression Patterns: Renin is primarily expressed in the juxtaglomerular cells of the kidneys . It is also found in other tissues, including the placenta .
Tissue Distribution: Renin is predominantly distributed in the kidneys but can also be detected in the plasma, liver, and other tissues .
Primary Biological Functions: The main function of renin is to regulate blood pressure and fluid balance through the RAAS . It converts angiotensinogen to angiotensin I, which is then converted to angiotensin II, leading to vasoconstriction and increased blood pressure .
Role in Immune Responses and Pathogen Recognition: While renin’s primary role is in blood pressure regulation, it also has implications in immune responses and inflammation .
Mechanisms with Other Molecules and Cells: Renin acts by cleaving angiotensinogen, produced by the liver, to form angiotensin I . Angiotensin I is then converted to angiotensin II by angiotensin-converting enzyme (ACE), primarily in the lungs .
Binding Partners and Downstream Signaling Cascades: Angiotensin II binds to AT1 and AT2 receptors, leading to various physiological effects, including vasoconstriction, aldosterone release, and increased sodium reabsorption .
Regulatory Mechanisms: Renin release is regulated by several factors, including blood pressure, sodium levels, and sympathetic nervous system activity . It is inhibited by atrial natriuretic peptide (ANP) and stimulated by prostaglandins and nitric oxide .
Transcriptional Regulation and Post-Translational Modifications: Renin gene expression is regulated at the transcriptional level by various factors, including cAMP and calcium . Post-translational modifications, such as glycosylation, also play a role in renin’s activity .
Biomedical Research: Renin is a key target in hypertension research. Transgenic mice models have been used to study the effects of renin on blood pressure regulation .
Diagnostic Tools: Renin levels are measured to diagnose and manage conditions like hypertension and heart failure .
Therapeutic Strategies: Renin inhibitors, ACE inhibitors, and angiotensin receptor blockers (ARBs) are used to treat hypertension and related cardiovascular diseases .
