Recombinant Proteins
Product List
CADM1 Human
Cell Adhesion Molecule 1 Human Recombinant
ICAM-1 Human
Intercellular Adhesion Molecule-1 Human Recombinant
The ICAM-1 is purified by proprietary chromatographic techniques.
ICAM1 Human HEK
Intercellular Adhesion Molecule-1 Human Recombinant HEK
ICAM1 Human, Sf9
Intercellular Adhesion Molecule-1 Human Recombinant, SF9
ICAM1 Mouse
Intercellular Adhesion Molecule-1 Mouse Recombinant
ICAM1 Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 466 amino acids (28-485 a.a) and having a molecular mass of 51.2kDa.
ICAM1 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
ICAM2 Human
Intercellular Adhesion Molecule-2 Human Recombinant
ICAM2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
ICAM3 Human
Intercellular Adhesion Molecule-3 Human Recombinant
ICAM3 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 698 amino acids (30-485 a.a) and having a molecular mass of 76.7kDa.
ICAM3 is fused to a 242 amino acid hIgG-His-Tag at C-terminus & purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
ICAM5 Human
Intercellular Adhesion Molecule-5 Human Recombinant
ICAM5 Human Recombinant produced in HEK293 is a single, glycosylated polypeptide chain containing 1052 amino acids (23-835 a.a) and having a molecular mass of 113.8kDa. ICAM5 is fused to a 239 amino acid hIgG-His-tag at C-terminus & purified by proprietary chromatographic techniques.
L1CAM Human
L1 Cell Adhesion Molecule Human Recombinant
L1CAM Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 1104 amino acids (20-1115a.a.) and having a molecular mass of 123.6kDa (Molecular size on SDS-PAGE will appear at approximately 100-150kDa).
L1CAM is expressed with a 8 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
NCAM1 Human
Neural Cell Adhesion Molecule 1 Human Recombinant
NCAM1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 593 amino acids (20-603 a.a) and having a molecular mass of 65.7kDa.
NCAM1 is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
Sterile filtered colorless solution.
Introduction
Intercellular Adhesion Molecules (ICAMs) are a group of cell surface glycoproteins that play a crucial role in the immune response by facilitating the adhesion and interaction of leukocytes with endothelial cells. They belong to the immunoglobulin superfamily and are classified into several types, including ICAM-1, ICAM-2, ICAM-3, ICAM-4, and ICAM-5, each with distinct structural and functional properties.
Key Biological Properties: ICAMs are characterized by their ability to mediate cell-cell adhesion, which is essential for immune surveillance and response. They possess immunoglobulin-like domains that facilitate binding to integrins on leukocytes.
Expression Patterns: ICAMs are expressed on various cell types, including endothelial cells, epithelial cells, and immune cells. Their expression can be upregulated in response to inflammatory cytokines such as TNF-α and IL-1β.
Tissue Distribution: ICAMs are widely distributed across different tissues, with high expression levels in the vascular endothelium, lymphoid organs, and sites of inflammation.
Primary Biological Functions: The primary function of ICAMs is to mediate the adhesion and transmigration of leukocytes across the endothelium during immune responses. They also play a role in antigen presentation and the activation of T cells.
Role in Immune Responses: ICAMs are critical for the recruitment of immune cells to sites of infection or injury. They facilitate the firm adhesion of leukocytes to the endothelium, allowing them to migrate into tissues and mount an effective immune response.
Pathogen Recognition: Some pathogens, such as rhinoviruses, exploit ICAMs as receptors to gain entry into host cells, highlighting their role in pathogen recognition and infection.
Mechanisms with Other Molecules and Cells: ICAMs interact with integrins, such as LFA-1 and Mac-1, on the surface of leukocytes. This interaction is crucial for the firm adhesion and transmigration of leukocytes.
Binding Partners: ICAMs bind to integrins on leukocytes, facilitating cell-cell adhesion. They also interact with other adhesion molecules and signaling receptors on endothelial and immune cells.
Downstream Signaling Cascades: The binding of ICAMs to integrins triggers intracellular signaling cascades that promote cytoskeletal rearrangements, cell migration, and the activation of immune responses.
Regulatory Mechanisms: The expression and activity of ICAMs are tightly regulated at multiple levels, including transcriptional and post-transcriptional mechanisms.
Transcriptional Regulation: The transcription of ICAM genes is regulated by various transcription factors, such as NF-κB and AP-1, which are activated in response to inflammatory stimuli.
Post-Translational Modifications: ICAMs undergo post-translational modifications, such as glycosylation, which are essential for their proper folding, stability, and function.
Biomedical Research: ICAMs are widely studied in biomedical research for their role in immune responses and inflammation. They serve as valuable models for understanding cell adhesion and signaling mechanisms.
Diagnostic Tools: Soluble forms of ICAMs (sICAMs) are used as biomarkers for various inflammatory and autoimmune diseases, such as rheumatoid arthritis and cardiovascular diseases.
Therapeutic Strategies: Targeting ICAMs with monoclonal antibodies or small molecules is being explored as a therapeutic strategy for treating inflammatory diseases, cancer, and viral infections.
Development: ICAMs play a role in embryonic development by mediating cell-cell interactions and tissue formation.
Aging: The expression and function of ICAMs can be altered with aging, contributing to age-related changes in immune function and inflammation.
Disease: Dysregulation of ICAM expression and function is associated with various diseases, including chronic inflammatory conditions, autoimmune diseases, and cancer.
