Recombinant Proteins
Product List
TRAPPC2 Human
Trafficking Protein Particle Complex 2 Human Recombinant
TRAPPC2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
TRAPPC2L Human
Trafficking Protein Particle Complex 2-Like Human Recombinant
TRAPPC3 Human
Trafficking Protein Particle Complex 3 Human Recombinant
TRAPPC3 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
TRAPPC4 Human
Trafficking Protein Particle Complex 4 Human Recombinant
TRAPPC4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
The Trafficking Protein Particle Complex (TRAPP) is a multi-subunit complex involved in the regulation of vesicular trafficking within cells. It is classified into two main types: TRAPP I and TRAPP II, each with distinct subunit compositions and functions. TRAPP I is primarily involved in the early stages of vesicle formation, while TRAPP II plays a role in later stages, including vesicle tethering and fusion.
Key Biological Properties: TRAPP complexes are essential for maintaining cellular homeostasis by regulating the transport of proteins and lipids between different cellular compartments. They are highly conserved across species, indicating their fundamental role in cellular processes.
Expression Patterns: TRAPP components are ubiquitously expressed in various tissues, with higher expression levels observed in metabolically active tissues such as the liver, brain, and pancreas.
Tissue Distribution: TRAPP complexes are found in multiple cellular compartments, including the endoplasmic reticulum, Golgi apparatus, and endosomes. Their distribution is crucial for their role in vesicular trafficking.
Primary Biological Functions: The primary function of TRAPP complexes is to facilitate the transport of vesicles between different cellular compartments. This includes the formation, tethering, and fusion of vesicles, ensuring the proper delivery of cargo molecules.
Role in Immune Responses: TRAPP complexes play a role in the immune response by regulating the trafficking of immune-related proteins and receptors. This ensures the proper functioning of immune cells and the effective recognition and response to pathogens.
Pathogen Recognition: TRAPP complexes are involved in the recognition and processing of pathogen-derived molecules, aiding in the activation of immune responses and the clearance of infections.
