TRAPPC2L Human

Trafficking Protein Particle Complex 2-Like Human Recombinant
Cat. No.
BT14562
Source
Escherichia Coli.
Synonyms
Trafficking protein particle complex subunit 2-like protein, TRAPPC2L.
Appearance
Sterile Filtered clear solution.
Purity
Greater than 90% as determined by SDS-PAGE.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
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Description

TRAPPC2L Human Recombinant produced in E. coli is a single polypeptide chain containing 162 amino acids (1-139) and having a molecular mass of 18.4kDa. TRAPPC2L is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Product Specs

Introduction
TRAPPC2L, also known as Trafficking Protein Particle Complex 2-Like, is a protein involved in the transportation of vesicles from the endoplasmic reticulum to the Golgi apparatus. It belongs to the TRAPP family and is found in various organs including the testis, liver, bladder, lung, spleen, and brain.
Description
This recombinant TRAPPC2L protein is produced in E. coli and consists of a single polypeptide chain of 162 amino acids (amino acids 1-139 of the native protein sequence) with a molecular weight of 18.4 kDa. It includes a 23 amino acid His-tag at the N-terminus to facilitate purification by chromatographic techniques.
Physical Appearance
A clear, sterile-filtered solution.
Formulation
The TRAPPC2L protein is supplied in a solution at a concentration of 0.5 mg/ml. The solution is buffered with 20mM Tris-HCl at pH 8.0 and contains 0.2M NaCl, 50% glycerol, and 2mM DTT.
Stability
For short-term storage (up to 4 weeks), keep refrigerated at 4°C. For extended storage, freeze at -20°C. Adding a carrier protein such as HSA or BSA to a final concentration of 0.1% is recommended for long-term storage. Avoid repeated freeze-thaw cycles.
Purity
The purity of the TRAPPC2L protein is greater than 90% as determined by SDS-PAGE analysis.
Synonyms
Trafficking protein particle complex subunit 2-like protein, TRAPPC2L.
Source
Escherichia Coli.
Amino Acid Sequence
MGSSHHHHHH SSGLVPRGSH MGSMAVCIAV IAKENYPLYI RSTPTENELK FHYMVHTSLD VVDEKISAMG KALVDQRELY LGLLYPTEDY KVYGYVTNSK VKFVMVVDSS NTALRDNEIR SMFRKLHNSY TDVMCNPFYN PGDRIQSRAF DNMVTSMMIQ VC.

Product Science Overview

Gene and Protein Structure

The TRAPPC2L gene is located on chromosome 16q24.3 . It contains at least four exons and encodes a protein consisting of 139 amino acids . The TRAPPC2L protein is expressed in various human hematopoietic cell lines .

Function

TRAPPC2L is involved in the early stages of vesicular transport between the endoplasmic reticulum (ER) and the Golgi apparatus . The TRAPP complex mediates the contact between vesicles and target membranes, facilitating the transport of proteins and lipids . Knockdown of individual components of the TRAPP complexes has been shown to cause Golgi fragmentation and arrest anterograde trafficking, highlighting the essential role of TRAPPC2L in maintaining Golgi structure and function .

Clinical Significance

Mutations in the TRAPPC2L gene have been associated with certain diseases. For example, a homozygous missense mutation (D37Y) in the TRAPPC2L gene has been identified in individuals with early-onset progressive encephalopathy with episodic rhabdomyolysis (PEERB) . This mutation causes a defect in intracellular trafficking, leading to the clinical manifestations of the disease .

Research and Applications

Recombinant TRAPPC2L protein is used in various research applications to study its function and role in vesicular trafficking. Understanding the mechanisms by which TRAPPC2L and the TRAPP complex operate can provide insights into the pathogenesis of diseases associated with vesicular transport defects and potentially lead to the development of therapeutic interventions.

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TRAPPC2 Human
Trafficking Protein Particle Complex 2 Human Recombinant
Cat. No.
BT13998
Source
Escherichia Coli.
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