Recombinant Proteins
Product List
SERTAD1 Human
SERTA Domain Containing 1 Human Recombinant
SERTAD1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
SERTAD2 Human
SERTA Domain Containing 2 Human Recombinant
SERTAD2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
The SERTA domain is a conserved protein motif found in a family of proteins known as SERTA domain-containing proteins. These proteins are involved in various cellular processes, including cell cycle regulation and transcriptional control. The SERTA domain is named after three proteins: SEI-1, RBT1, and TRIP-Br1, which share this motif .
Key Biological Properties: SERTA domain-containing proteins are involved in the regulation of cell proliferation and transcription. They are known to interact with other proteins to modulate their activity.
Expression Patterns: The expression of SERTA domain-containing proteins varies across different tissues. For instance, SERTAD1, a well-studied member of this family, is expressed in various tissues, including the brain, liver, and heart .
Tissue Distribution: SERTAD1 is predominantly localized in the nucleus and cytoplasm of cells. It is involved in the regulation of transcription and cell cycle progression .
Primary Biological Functions: SERTA domain-containing proteins play a crucial role in regulating transcription and cell cycle progression. They act as co-regulators at E2F-responsive promoters, integrating signals from PHD- and bromodomain-containing transcription factors .
Role in Immune Responses and Pathogen Recognition: While the primary focus of SERTA domain-containing proteins is on cell cycle regulation and transcription, they may also play a role in immune responses by modulating the activity of transcription factors involved in immune signaling .
Mechanisms with Other Molecules and Cells: SERTA domain-containing proteins interact with various other proteins to exert their regulatory functions. For example, SERTAD1 interacts with cyclin-dependent kinase 4 (CDK4) and enhances its activity by rendering it resistant to the inhibitory effects of CDKN2A/p16INK4A .
Binding Partners and Downstream Signaling Cascades: SERTAD1 binds to E2F1/TFDP1 transcription factors, stimulating their transcriptional activity. This interaction is crucial for the regulation of genes involved in cell cycle progression .
Regulatory Mechanisms Controlling Expression and Activity: The expression and activity of SERTA domain-containing proteins are regulated at multiple levels, including transcriptional and post-translational modifications. For instance, the transcription of SERTAD1 is regulated by various transcription factors, while its activity can be modulated by phosphorylation .
Transcriptional Regulation: SERTAD1 is regulated by transcription factors that bind to its promoter region, influencing its expression levels .
Post-Translational Modifications: Phosphorylation is a key post-translational modification that regulates the activity of SERTA domain-containing proteins. This modification can alter their interaction with other proteins and their stability .
Biomedical Research: SERTA domain-containing proteins are studied for their role in cell cycle regulation and transcription. Understanding their function can provide insights into the mechanisms of cell proliferation and cancer development .
Diagnostic Tools: The expression levels of SERTA domain-containing proteins, such as SERTAD1, can serve as biomarkers for certain diseases, including cancer .
Therapeutic Strategies: Targeting the interactions and regulatory mechanisms of SERTA domain-containing proteins can be a potential therapeutic strategy for diseases characterized by abnormal cell proliferation, such as cancer .
Role Throughout the Life Cycle: SERTA domain-containing proteins play a role in various stages of the life cycle, from development to aging. They are involved in the regulation of cell proliferation during development and can influence the aging process by modulating the activity of transcription factors involved in cell cycle regulation .
Development to Aging and Disease: Abnormal expression or activity of SERTA domain-containing proteins can lead to diseases such as cancer. Understanding their role in the life cycle can provide insights into the mechanisms of disease development and potential therapeutic targets .
