SERTAD2 Human
Description
SERTAD2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Specs
Product Science Overview
The SERTAD2 gene is located on chromosome 2 and is a protein-coding gene . The protein itself contains a SERTA domain, which is a specific sequence motif that is involved in protein-protein interactions. The recombinant form of this protein is often produced in E. coli expression systems and can be tagged with His-ABP for purification purposes .
SERTAD2 acts as a coregulator at E2F-responsive promoters, integrating signals provided by PHD- and/or bromodomain-containing transcription factors . It can function both as a coactivator and a corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites. This dual role allows it to either activate or inhibit the expression of E2F-target genes .
Additionally, SERTAD2 modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis, and oxidative metabolism . This makes it a significant player in metabolic regulation and energy homeostasis.
Mutations or dysregulation of the SERTAD2 gene have been associated with various diseases, including Superior Mesenteric Artery Syndrome and Duodenal Obstruction . Understanding the function and regulation of SERTAD2 can provide insights into these conditions and potentially lead to new therapeutic approaches.
Recombinant SERTAD2 protein is widely used in research to study its function and interactions. It is often used in blocking assays and control experiments to investigate the role of SERTAD2 in gene regulation . The protein’s ability to interact with transcription factors makes it a valuable tool for studying transcriptional regulation mechanisms.
