Recombinant Proteins
Product List
p53 Human
p53 Protein Human Recombinant
Introduction
Key Biological Properties: p53 is a sequence-specific DNA-binding transcription factor that regulates gene expression in response to various cellular stresses . It is involved in multiple cellular functions, including cell cycle arrest, apoptosis, DNA repair, and metabolism .
Expression Patterns: p53 is expressed at low levels in normal cells but is upregulated in response to stress signals such as DNA damage .
Tissue Distribution: p53 is ubiquitously expressed in various tissues, with higher expression levels observed in tissues with high cell turnover rates, such as the bone marrow, thymus, and intestinal epithelium .
Primary Biological Functions: p53 plays a pivotal role in maintaining genomic stability by preventing the proliferation of cells with damaged DNA. It induces cell cycle arrest, apoptosis, senescence, and DNA repair .
Role in Immune Responses and Pathogen Recognition: p53 is involved in the regulation of immune responses by modulating the expression of immune-related genes. It also plays a role in pathogen recognition and the activation of immune cells .
Mechanisms with Other Molecules and Cells: p53 interacts with various molecules and cellular components to exert its functions. It binds to specific DNA sequences to regulate gene expression and interacts with proteins involved in cell cycle regulation, apoptosis, and DNA repair .
Binding Partners and Downstream Signaling Cascades: p53 forms complexes with proteins such as MDM2, which regulates its stability and activity. It also activates downstream signaling cascades that lead to cell cycle arrest, apoptosis, and DNA repair .
Transcriptional Regulation: p53 is regulated at the transcriptional level by various factors, including stress signals that activate its expression .
Post-Translational Modifications: p53 undergoes post-translational modifications, such as phosphorylation and acetylation, which regulate its stability and activity. MDM2-mediated ubiquitination leads to its proteasomal degradation .
Biomedical Research: p53 is extensively studied in cancer research due to its role as a tumor suppressor. Understanding its functions and regulatory mechanisms provides insights into cancer development and potential therapeutic targets .
Diagnostic Tools: p53 mutations are commonly found in various cancers, making it a valuable biomarker for cancer diagnosis and prognosis .
Therapeutic Strategies: Therapeutic strategies targeting p53 include restoring its wild-type function, inhibiting its negative regulators, and exploiting synthetic lethal interactions with mutant p53 .
Development to Aging and Disease: p53 plays a critical role throughout the life cycle. During development, it ensures proper cell proliferation and differentiation. In adulthood, it maintains genomic stability and prevents tumor formation. In aging, p53 activity can contribute to cellular senescence and age-related diseases .
