Recombinant Proteins
Product List
MAGEA3 Human
Melanoma Antigen Family A, 3 Human Recombinant
MAGEA3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
MAGEA4 Human
Melanoma Antigen Family A, 4 Human Recombinant
MAGEA5 Human
Melanoma Antigen Family A, 5 Human Recombinant
MAGEA5 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
MAGEA6 Human
Melanoma Antigen Family A, 6 Human Recombinant
MAGEA6 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
MAGEA8 Human
Melanoma Antigen Family A, 8 Human Recombinant
MAGEA8 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
MAGEB10 Human
Melanoma Antigen Family B,10 Human Recombinant
MAGED1 Human
Melanoma Antigen Family D, 1 Human Recombinant
MAGED1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
The Melanoma Antigen Family A (MAGE-A) is a subgroup of the larger Melanoma Antigen Gene (MAGE) family, which belongs to the cancer/testis (CT) antigen group. These antigens are characterized by their restricted expression in immune-privileged tissues such as the testis and various cancers . MAGE-A proteins are presented on the cell surface by MHC class I molecules, making them potential targets for cancer immunotherapy .
Key Biological Properties: MAGE-A proteins share a conserved MAGE homology domain (MHD), which is highly conserved within the subfamily .
Expression Patterns: MAGE-A proteins exhibit restricted expression in reproductive tissues but are abnormally expressed in various human malignancies .
Tissue Distribution: These proteins are primarily found in germline cells and a wide range of cancers, including bladder cancer, where they are associated with increased cancer cell proliferation, survival, and resistance to therapies .
Primary Biological Functions: MAGE-A proteins play a crucial role in tumorigenesis and cancer cell survival . They are involved in driving cancer progression, metastasis, and therapeutic recurrence .
Role in Immune Responses: MAGE-A proteins are recognized by cytotoxic T lymphocytes, which induce a robust immune response against developing cancer cells .
Pathogen Recognition: While primarily involved in cancer, MAGE-A proteins also contribute to immune responses by presenting unique cancer epitopes on the cell surface .
Mechanisms with Other Molecules and Cells: MAGE-A proteins interact with various molecules and cells through their presentation on MHC class I molecules .
Binding Partners: They bind to cytotoxic T lymphocytes, facilitating the immune response against cancer cells .
Downstream Signaling Cascades: The interaction of MAGE-A proteins with immune cells triggers downstream signaling cascades that lead to the destruction of cancer cells .
Biomedical Research: MAGE-A proteins are extensively studied as biomarkers for cancer diagnosis and prognosis .
Diagnostic Tools: Their restricted expression in cancers makes them ideal targets for developing diagnostic assays .
Therapeutic Strategies: MAGE-A proteins are targeted in cancer immunotherapy, including cancer vaccines and adoptive T-cell transfer therapies .
Development: MAGE-A proteins are involved in germ cell development and are expressed during spermatogenesis and embryonic development .
Aging and Disease: Their expression is typically silenced in normal adult tissues but reactivated in various cancers, contributing to cancer progression and resistance to therapies .
