Recombinant Proteins
Product List
HN1 Human
Hematological And Neurological Expressed 1 Human Recombinant
HN1L Human
Hematological and Neurological Expressed 1-Like Human Recombinant
Introduction
Hematological and Neurological Expressed 1 (HN1), also known as Jupiter microtubule-associated homolog 1 (JPT1), is a highly conserved protein encoded by the HN1 gene. It is classified under the family of proteins involved in cellular growth and differentiation. HN1 is expressed in a wide range of tissues, with particularly high levels in hematopoietic cells and fetal brain tissues .
Key Biological Properties: HN1 is a 154-amino acid protein that plays a crucial role in cellular processes such as proliferation, differentiation, and apoptosis. It is highly conserved across species, indicating its fundamental role in biological systems .
Expression Patterns: HN1 exhibits a broad expression pattern, being present in various tissues including the brain, liver, and hematopoietic cells. Its expression is particularly elevated in fetal brain tissues and hematopoietic cells .
Tissue Distribution: HN1 is widely distributed across different tissues, with the highest expression levels observed in hematopoietic cells and fetal brain tissues. It is also present in other tissues such as the liver, kidney, and various cancerous tissues .
Primary Biological Functions: HN1 is involved in several critical biological functions, including cell proliferation, differentiation, and apoptosis. It plays a significant role in the development of hematopoietic cells and the nervous system .
Role in Immune Responses and Pathogen Recognition: HN1 has been implicated in immune responses, particularly in the regulation of hematopoietic cell development. It may also play a role in pathogen recognition, although this aspect requires further investigation .
Mechanisms with Other Molecules and Cells: HN1 interacts with various molecules and cells to exert its effects. It has been shown to regulate the mTOR signaling pathway, which is crucial for cell growth and metabolism .
Binding Partners and Downstream Signaling Cascades: HN1 binds to several proteins, including those involved in the mTOR signaling pathway. This interaction leads to the activation of downstream signaling cascades that promote cell proliferation, migration, and survival .
Transcriptional Regulation: The expression of HN1 is regulated at the transcriptional level by various transcription factors. These factors bind to the promoter region of the HN1 gene and modulate its transcription .
Post-Translational Modifications: HN1 undergoes several post-translational modifications, including phosphorylation and ubiquitination. These modifications regulate its stability, localization, and activity within the cell .
Biomedical Research: HN1 is a valuable target in biomedical research due to its role in cell proliferation and differentiation. It is studied extensively in the context of cancer and developmental biology .
Diagnostic Tools: HN1 expression levels can serve as a diagnostic marker for various cancers. Elevated levels of HN1 have been associated with poor prognosis in cancers such as ovarian and breast cancer .
Therapeutic Strategies: Targeting HN1 and its associated signaling pathways offers potential therapeutic strategies for treating cancers. Inhibitors of the mTOR pathway, which is regulated by HN1, are being explored as potential cancer treatments .
Development: HN1 plays a crucial role in embryonic development, particularly in the development of the nervous system and hematopoietic cells .
Aging and Disease: The expression and activity of HN1 are implicated in aging and various diseases, including cancer. Dysregulation of HN1 expression can lead to uncontrolled cell proliferation and tumorigenesis .
