Recombinant Proteins
Product List
HINT1 Human
Histidine Triad Nucleotide Binding Protein 1 Human Recombinant
The HINT1 is purified by proprietary chromatographic techniques.
HINT2 Human
Histidine Triad Nucleotide Binding Protein 2 Human Recombinant
HINT2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
HINT (Histidine Triad Nucleotide-binding protein) is a member of the HIT (Histidine Triad) protein superfamily. These proteins are characterized by a conserved histidine triad motif (H-X-H-X-H-X-X), where “H” represents histidine and “X” represents any amino acid. HINT proteins are found in both prokaryotic and eukaryotic organisms and are involved in various biochemical processes .
HINT proteins exhibit several key biological properties:
- Expression Patterns: HINT proteins are ubiquitously expressed in various tissues, indicating their fundamental role in cellular processes.
- Tissue Distribution: They are found in a wide range of tissues, including the brain, liver, and muscle, suggesting their involvement in diverse physiological functions .
HINT proteins play crucial roles in several biological functions:
- Primary Biological Functions: They are involved in the hydrolysis of nucleotide derivatives, which is essential for maintaining cellular nucleotide balance.
- Role in Immune Responses and Pathogen Recognition: HINT proteins participate in immune responses by modulating the activity of immune cells and recognizing pathogen-associated molecular patterns .
HINT proteins interact with other molecules and cells through various mechanisms:
The expression and activity of HINT proteins are tightly regulated:
- Transcriptional Regulation: The transcription of HINT genes is controlled by various transcription factors that respond to cellular and environmental cues.
- Post-translational Modifications: HINT proteins undergo post-translational modifications, such as phosphorylation, which modulate their activity and stability .
HINT proteins have several applications in biomedical research:
- Diagnostic Tools: They can be used as biomarkers for diagnosing certain diseases due to their altered expression patterns in pathological conditions.
- Therapeutic Strategies: Targeting HINT proteins with specific inhibitors or activators can be a potential therapeutic strategy for treating diseases associated with their dysregulation .
HINT proteins play significant roles throughout the life cycle:
