Recombinant Proteins
Product List
CRISP1 Human
Cysteine-Rich Secretory Protein 1 Human Recombinant
CRISP1 is fused to 10 amino acids His-Tag at N-terminus and purified by proprietary chromatographic techniques.
CRISP2 Human
Cysteine-Rich Secretory Protein 2 Human Recombinant
CRISP3 Human
Cysteine-Rich Secretory Protein 3 Human Recombinant
Introduction
Cysteine-Rich Secretory Proteins (CRISPs) are a group of glycoproteins characterized by their high cysteine content, which forms disulfide bonds crucial for their structure and function . They belong to the CAP superfamily, which includes CRISP, antigen 5, and pathogenesis-related 1 (PR-1) proteins . CRISPs are found in various organisms, including mammals and snakes, and play significant roles in reproduction and venom toxicity .
CRISPs exhibit several key biological properties:
- Expression Patterns: CRISPs are predominantly expressed in the male reproductive tract, particularly in the testes and epididymis .
- Tissue Distribution: They are found in spermatozoa, seminal fluid, and various snake venoms .
- Stability: Their structure is stabilized by multiple disulfide bonds, providing high thermal and chemical stability .
CRISPs have diverse biological functions:
- Reproduction: They are involved in spermatogenesis, sperm motility, and fertilization . CRISP2, for example, plays a role in sperm-egg fusion .
- Immune Responses: Some CRISPs are implicated in immune defense mechanisms .
- Pathogen Recognition: They may also participate in recognizing and neutralizing pathogens .
CRISPs interact with other molecules and cells through various mechanisms:
The expression and activity of CRISPs are tightly regulated:
