Recombinant Proteins
Product List
Calumenin Human
Calumenin Human Recombinant
Calumenin Human Recombinant produced in E. coli is a single polypeptide chain containing 297 amino acids (20-315) and having a molecular mass of 35kDa. Calumenin is purified by proprietary chromatographic techniques.
Calumenin Human, His
Calumenin Human Recombinant, His Tag
Introduction
Key Biological Properties: Calumenin is involved in calcium ion binding and protein folding within the ER. It contains six EF-hand motifs, one potential N-glycosylation site, and a C-terminal ER retention signal .
Expression Patterns: Calumenin mRNA is ubiquitously expressed in human tissues, including the endometrium, smooth muscle tissue, and various arteries .
Tissue Distribution: It is highly expressed in stromal cells of the endometrium, smooth muscle tissue, and various arteries, indicating its widespread role in different tissues .
Primary Biological Functions: Calumenin functions as a molecular chaperone, assisting in protein folding and sorting within the ER. It also plays a role in calcium cycling, vascular calcification, thrombosis, cell migration, and apoptosis .
Role in Immune Responses and Pathogen Recognition: Calumenin has been implicated in immune responses, particularly in the regulation of interferon signals and inflammatory pathways .
Mechanisms with Other Molecules and Cells: Calumenin interacts with various ER proteins, including sarco-endoplasmic reticulum calcium ATPase (SERCA) pumps, and regulates ER stress by modulating the expression of ER-stress proteins .
Binding Partners: It binds to proteins involved in calcium signaling and γ-carboxylation processes .
Downstream Signaling Cascades: Calumenin influences signaling pathways such as MYC and KRAS, while activating interferon and inflammatory pathways .
Transcriptional Regulation: The expression of calumenin is regulated at the transcriptional level, with increased expression observed in various cancers .
Post-Translational Modifications: Calumenin undergoes post-translational modifications, including glycosylation, which may affect its function and localization .
Biomedical Research: Calumenin is studied for its role in cancer progression, particularly in lung adenocarcinoma and clear cell renal cell carcinoma .
Diagnostic Tools: Its expression levels can serve as biomarkers for certain cancers, aiding in diagnosis and prognosis .
Therapeutic Strategies: Targeting calumenin may offer therapeutic potential in treating cancers and other diseases associated with ER stress and calcium dysregulation .
Development to Aging and Disease: Calumenin plays a crucial role throughout the life cycle, from development to aging. It is involved in muscle contraction-relaxation processes and has been linked to various diseases, including cancer and cardiovascular diseases .
Calumenin’s multifaceted roles in cellular processes and disease mechanisms make it a significant protein of interest in biomedical research and therapeutic development.
