Recombinant Proteins
Product List
BTF3 Human
Basic Transcription Factor 3 Human Recombinant
BTF3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
BTF3L4 Human
Basic Transcription Factor 3-Like 4 Human Recombinant
BTF3L4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
A transcription factor (TF) is a protein that binds to specific DNA sequences, thereby controlling the rate of transcription of genetic information from DNA to messenger RNA . Transcription factors can act as activators or repressors of gene transcription. They are classified based on their DNA-binding domains (DBDs), which include zinc finger, helix-turn-helix, leucine zipper, and helix-loop-helix motifs .
Key Biological Properties: Transcription factors are modular in structure, typically containing a DNA-binding domain, a transactivation domain, and sometimes a dimerization domain . They are essential for the regulation of gene expression and are involved in various cellular processes such as cell growth, differentiation, and apoptosis .
Expression Patterns and Tissue Distribution: The expression of transcription factors is tightly regulated and can be tissue-specific. For example, some transcription factors are ubiquitously expressed, while others are restricted to specific tissues or developmental stages .
Primary Biological Functions: Transcription factors play a crucial role in the regulation of gene expression, allowing cells to respond to internal and external signals . They are involved in processes such as cell differentiation, development, and response to environmental stimuli .
Role in Immune Responses and Pathogen Recognition: Certain transcription factors are key regulators of the immune response. For example, NF-κB is a transcription factor that plays a critical role in the regulation of immune responses and inflammation .
Transcription factors exert their effects by binding to specific DNA sequences in the promoter or enhancer regions of target genes . This binding can either promote or inhibit the recruitment of RNA polymerase, thereby regulating the transcription of the gene . Transcription factors can also interact with other proteins, such as coactivators and corepressors, to modulate gene expression .
Transcriptional Regulation: Transcription factors can regulate gene expression by stabilizing or blocking the binding of RNA polymerase to DNA . They can also recruit other proteins that modify chromatin structure, such as histone acetyltransferases and deacetylases .
Post-Translational Modifications: The activity of transcription factors can be regulated by post-translational modifications, such as phosphorylation, acetylation, and ubiquitination . These modifications can affect the stability, localization, and DNA-binding affinity of transcription factors .
Biomedical Research: Transcription factors are widely studied in biomedical research due to their role in gene regulation and disease . They are used as tools to understand the mechanisms of gene expression and to identify potential therapeutic targets .
Diagnostic Tools and Therapeutic Strategies: Transcription factors can serve as biomarkers for the diagnosis of diseases. For example, the overexpression of certain transcription factors is associated with cancer . Additionally, targeting transcription factors with small molecules or other therapeutic agents is a promising strategy for the treatment of various diseases .
Transcription factors play a vital role throughout the life cycle of an organism . During development, they regulate the expression of genes involved in cell differentiation and organogenesis . In adulthood, they maintain cellular homeostasis and regulate responses to environmental changes . Dysregulation of transcription factors can lead to aging-related diseases and other pathological conditions .
