Recombinant Proteins
Product List
CRP (19-224 a.a) Human
c-Reactive Protein (19-224 a.a) Human Recombinant
CRP is purified by proprietary chromatographic techniques.
CRP Canine
C-Reactive Protein Canine Recombinant
CRP Canine Recombinant is a single, glycosylated polypeptide chain containing 204 amino acids and having a molecular mass of 23.2kDa (calculated).
HEK293 cells.
CRP Human
C-Reactive Protein Human
It can be used as a marker for inflammation and also used for monitoring and prediction of future events in coronary artery disease.
CRP Human Recombinant
c-Reactive Protein Human Recombinant
CRP Mouse
C-Reactive Protein Mouse Recombinant
CRP Mouse Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 214 amino acids (20-225 a.a) and having a molecular mass of 24.1 kDa.
CRP is fused to a 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.
Sf9, Baculovirus cells.
CRP Rat
C-Reactive Protein Rat Recombinant
CRP is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Introduction
C-Reactive Protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells . CRP is a member of the pentraxin family of proteins .
Key Biological Properties: CRP is synthesized by the liver in response to factors released by macrophages, T cells, and adipocytes . It is characterized by its pentameric structure and calcium-dependent binding to ligands like phosphocholine .
Expression Patterns and Tissue Distribution: CRP is primarily expressed in the liver, but it can also be found in other tissues such as the pancreas, gallbladder, and testicles . Its expression is highly upregulated during inflammatory conditions .
Primary Biological Functions: CRP plays a crucial role in the body’s immune response. It binds to lysophosphatidylcholine expressed on the surface of dead or dying cells and some types of bacteria, thereby activating the complement system via C1q . This process helps in the clearance of pathogens and damaged cells .
Role in Immune Responses and Pathogen Recognition: CRP enhances phagocytosis by binding to pathogens and facilitating their recognition by immune cells . It also modulates inflammation by interacting with immune cells, cytokines, and endothelial cells .
Mechanisms with Other Molecules and Cells: CRP activates certain parts of the immune system, specifically white blood cells called macrophages that clear foreign attackers and dead or dying cells from the body . It binds to specific pathogens and damaged cells, initiating the activation of the complement system .
Binding Partners and Downstream Signaling Cascades: CRP binds to phosphocholine on the surface of pathogens and damaged cells, which leads to the activation of the classical complement pathway . This activation results in a cascade of immune responses that help eliminate the foreign invaders .
Regulatory Mechanisms Controlling Expression and Activity: The synthesis of CRP in hepatocytes is mainly regulated at the transcription level by cytokines such as interleukin-6 (IL-6) and interleukin-1β (IL-1β) . Transcription factors like STAT3, Rel p50, c-Rel, and C/EBPβ/δ are involved in the regulation of CRP expression .
Transcriptional Regulation and Post-Translational Modifications: CRP expression is upregulated in response to inflammatory cytokines, and its activity can be modulated by post-translational modifications .
Biomedical Research: CRP is widely used as a biomarker in biomedical research to study inflammation and immune responses .
Diagnostic Tools: CRP levels are measured in clinical settings to diagnose and monitor various inflammatory conditions, including infections, autoimmune diseases, and cardiovascular diseases .
Therapeutic Strategies: CRP is being explored as a potential therapeutic target for treating inflammatory diseases and conditions associated with elevated CRP levels .
Role Throughout the Life Cycle: CRP plays a significant role in the body’s response to inflammation throughout the life cycle. Its levels can indicate the presence of inflammation during various stages of life, from development to aging and disease . Elevated CRP levels are associated with several age-related disorders and chronic inflammatory conditions .
