Recombinant Proteins
Product List
COPS6 Human
COP9 Constitutive Photomorphogenic 6 Human Recombinant
COPS6 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
COPS7A Human
COP9 Signalosome Subunit 7A Human Recombinant
COPS7A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
COPS8 Human
COP9 Constitutive Photomorphogenic 8 Human Recombinant
COPS8 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
The COP9 Signalosome (CSN) is a highly conserved protein complex found in all eukaryotic organisms, including plants, animals, and fungi . It was originally identified in plants as a regulator of light-mediated development . The CSN complex is composed of eight subunits, designated as CSN1 to CSN8 . Each subunit plays a crucial role in the overall function of the complex, and mutations in some of these subunits can be lethal .
The CSN complex exhibits several key biological properties:
- Expression Patterns: The CSN is ubiquitously expressed in various tissues and cell types .
- Tissue Distribution: It is found in both the nucleus and cytoplasm of cells .
- Key Biological Properties: The CSN regulates protein degradation by controlling the activity of cullin-RING ubiquitin ligases (CRLs) . It also plays a role in cell cycle regulation, DNA repair, and gene expression .
The primary biological functions of the CSN include:
- Regulation of Protein Degradation: The CSN controls the ubiquitin-proteasome system by regulating CRLs .
- Role in Immune Responses: The CSN is involved in the regulation of immune responses by modulating the activity of key signaling proteins .
- Pathogen Recognition: The CSN has been shown to play a role in the recognition and response to pathogens in various organisms .
The CSN exerts its effects through several mechanisms:
- Interaction with Other Molecules and Cells: The CSN interacts with CRLs and other signaling proteins to regulate their activity .
- Binding Partners: The CSN binds to CRLs and other proteins involved in the ubiquitin-proteasome system .
- Downstream Signaling Cascades: The CSN regulates downstream signaling pathways by modulating the activity of key signaling proteins .
The expression and activity of the CSN are tightly regulated through various mechanisms:
The CSN has several applications in biomedical research and therapeutic strategies:
- Biomedical Research: The CSN is a valuable tool for studying protein degradation and signaling pathways .
- Diagnostic Tools: The CSN can be used as a biomarker for certain diseases, such as cancer .
- Therapeutic Strategies: Targeting the CSN has potential therapeutic applications in the treatment of cancer and parasitic infections .
The CSN plays a crucial role throughout the life cycle of organisms:
