Recombinant Proteins
Product List
SEPT2 Human
Septin-2 Human Recombinant
SEPT3 Human
Septin-3 Human Recombinant
SEPT5 Human
Septin-5 Human Recombinant
The SEPT5 is fused to a 23 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
SEPT6 Human
Septin-6 Human Recombinant
SEPT6 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
Septins are a group of highly conserved GTP-binding proteins found in eukaryotic cells, excluding plants . They are part of the cytoskeleton and are involved in various cellular processes. Septins can form hetero-oligomeric complexes that assemble into filaments, rings, and gauzes . These proteins are classified based on their sequence homology and structural features, with humans having 13 different septin genes .
Key Biological Properties: Septins are known for their ability to bind and hydrolyze GTP, which is crucial for their function in filament formation . They have a conserved GTP-binding domain, a septin unique element (SUE), and a coiled-coil domain .
Expression Patterns and Tissue Distribution: Septins are ubiquitously expressed in various tissues, with specific septins showing distinct expression patterns. For example, Sept7 is widely expressed in the brain, heart, and skeletal muscles . Their expression can vary depending on the cell type and developmental stage .
Primary Biological Functions: Septins play a critical role in cytokinesis, cell polarity, and vesicle trafficking . They act as scaffolds for recruiting other proteins and form diffusion barriers to compartmentalize cellular regions .
Role in Immune Responses and Pathogen Recognition: Septins are involved in the immune response by forming cages around pathogenic bacteria, preventing their spread . They also participate in phagocytosis and the formation of the immune synapse .
Mechanisms with Other Molecules and Cells: Septins interact with various cellular components, including actin filaments, microtubules, and cell membranes . They form complexes through their GTP-binding domains and N- and C-terminal interactions .
Binding Partners and Downstream Signaling Cascades: Septins bind to proteins such as anillin, Borg proteins, and kinases, influencing downstream signaling pathways involved in cell division and cytoskeletal organization .
Biomedical Research: Septins are studied for their role in cancer, neurodegenerative diseases, and infectious diseases . They serve as biomarkers for certain cancers and are potential targets for therapeutic interventions .
Diagnostic Tools and Therapeutic Strategies: Septins are used in diagnostic assays to detect cancer and other diseases. Therapeutic strategies targeting septins include small molecules that disrupt septin filament formation and function .
Role Throughout the Life Cycle: Septins are essential for various stages of the life cycle, from embryonic development to aging . They are involved in processes such as cell division, differentiation, and maintenance of cellular integrity . Dysregulation of septin function is associated with aging-related diseases and cancer .
