Recombinant Proteins
Product List
LECT1 (214-333) Human
Leukocyte Cell Derived Chemotaxin 1 (214-333 a.a.) Human Recombinant
LECT1 Human
Leukocyte Cell Derived Chemotaxin 1 Human Recombinant
LECT2 Human
Leukocyte Cell-Derived Chemotaxin 2 Human Recombinant
Introduction
Leukocyte Cell Derived Chemotaxin 2 (LECT2) is a protein-coding gene that encodes a secreted protein with chemotactic activity. It is also known as Chondromodulin-II (ChM-II) due to its role in promoting chondrocyte proteoglycan synthesis and cartilage growth . LECT2 belongs to the peptidase M23 family and is classified as a multifunctional secreted factor involved in various physiological and pathological processes .
Key Biological Properties: LECT2 is a 16 kDa protein that acts as a chemotactic factor for neutrophils and stimulates the growth of chondrocytes and osteoblasts . It does not exhibit metalloendopeptidase activity .
Expression Patterns: LECT2 is primarily expressed in the liver, but it is also found in other tissues such as the kidney, lung, and various immune cells .
Tissue Distribution: The protein is secreted into the bloodstream and can be detected in various tissues, including the liver, kidney, and lung .
Primary Biological Functions: LECT2 plays a crucial role in immune responses by mediating neutrophil migration and acting as an antiviral regulator . It is also involved in promoting chondrocyte proliferation and cartilage growth .
Role in Immune Responses: LECT2 is associated with many immune processes and immune-related diseases via its binding to cell surface receptors such as CD209a, Tie1, and Met in various cell types .
Pathogen Recognition: LECT2 enhances the RIG-I-mediated innate immune response by promoting interferon production and inhibiting viral replication .
Mechanisms with Other Molecules and Cells: LECT2 binds to cell surface receptors such as CD209a, Tie1, and Met, facilitating various signaling pathways . It also interacts with the MET receptor tyrosine kinase, promoting the recruitment of phosphatase PTP4A1 to MET and protecting RIG-I from degradation .
Binding Partners: LECT2 binds to receptors like CD209a, Tie1, and Met, which are involved in immune responses and other physiological processes .
Downstream Signaling Cascades: Upon binding to its receptors, LECT2 activates various signaling pathways, including the VEGF165-VEGFR2 signaling in liver cancer and the LECT2-Tie1 signaling in liver fibrosis .
Transcriptional Regulation: The expression of LECT2 is regulated at the transcriptional level by various factors, including cytokines and growth factors .
Post-Translational Modifications: LECT2 undergoes post-translational modifications such as glycosylation, which are essential for its stability and function .
Biomedical Research: LECT2 is used as a biomarker in various diseases, including liver fibrosis, hepatic cell carcinoma, and systemic inflammatory diseases .
Diagnostic Tools: LECT2 levels can be measured in blood samples to diagnose and monitor the progression of certain diseases .
Therapeutic Strategies: Targeting LECT2 and its signaling pathways holds potential for developing therapeutic interventions for immune-related diseases and cancer .
Development: LECT2 plays a role in cartilage growth and chondrocyte proliferation during development .
Aging and Disease: LECT2 is involved in various age-related diseases, including liver fibrosis and amyloidosis . Its misfolding can lead to the formation of insoluble fibrils, contributing to tissue amyloidosis .
