Recombinant Proteins
Product List
ING1 Human
Inhibitor of Growth Family, Member 1 Human Recombinant
ING1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
ING2 Human
Inhibitor of Growth Family, Member 2 Human Recombinant
ING2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
The Inhibitor of Growth (ING) family consists of tumor suppressor genes that play crucial roles in regulating cell proliferation, apoptosis, and cellular senescence. This family includes five members: ING1, ING2, ING3, ING4, and ING5 . These proteins are highly conserved across species and are known to be downregulated in various human malignancies .
Key Biological Properties: ING proteins are involved in chromatin remodeling and act as readers of histone modification marks. They contain several domains that allow them to bind to chromatin structures and interact with other proteins such as p53 .
Expression Patterns and Tissue Distribution: The expression of ING proteins varies across different tissues. They are generally expressed in a wide range of tissues, but their levels can be significantly altered in cancerous tissues .
Primary Biological Functions: ING proteins function as tumor suppressors by regulating cell cycle progression, promoting apoptosis, and inducing cellular senescence .
Role in Immune Responses and Pathogen Recognition: ING proteins, particularly ING4, have been shown to play roles in innate immunity and angiogenesis . They help in the recognition and response to pathogens by modulating the activity of immune cells.
Mechanisms with Other Molecules and Cells: ING proteins interact with various molecules and cellular structures to exert their effects. They bind to histone marks and recruit histone acetyltransferase (HAT) or histone deacetylase (HDAC) complexes to alter chromatin structure .
Binding Partners and Downstream Signaling Cascades: ING proteins interact with several binding partners, including p53 and NF-κB, to regulate downstream signaling pathways involved in cell cycle control, apoptosis, and DNA repair .
Transcriptional Regulation: The expression of ING genes is regulated at the transcriptional level by various transcription factors and signaling pathways .
Post-Translational Modifications: ING proteins undergo post-translational modifications such as phosphorylation and acetylation, which can affect their stability, localization, and activity .
Biomedical Research: ING proteins are studied extensively in cancer research due to their tumor suppressor functions. They are potential biomarkers for cancer diagnosis and prognosis .
Diagnostic Tools and Therapeutic Strategies: ING proteins can be used as diagnostic markers to identify cancerous tissues. Therapeutically, targeting ING proteins or their pathways could provide new strategies for cancer treatment .
Development to Aging and Disease: ING proteins play roles throughout the life cycle, from development to aging. They are involved in regulating cell growth and differentiation during development and help maintain cellular homeostasis in adult tissues. Dysregulation of ING proteins is associated with aging-related diseases and cancer .
