Recombinant Proteins
Product List
TBCA Human
Tubulin Folding Cofactor A Human Recombinant
The TBCA is purified by proprietary chromatographic techniques.
TBCB Human
Tubulin Folding Cofactor B Human Recombinant
TBCB is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
TBCC Human
Tubulin Folding Cofactor C Human Recombinant
TBCC is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
TBCEL Human
Tubulin Folding Cofactor E-Like Human Recombinant
TPPP3 Human
Tubulin Polymerization-Promoting Protein Family Member 3 Human Recombinant
Introduction
Tubulin Folding Cofactors (TFCs) are a group of proteins essential for the proper folding and assembly of tubulin, the building block of microtubules. These cofactors are classified into five main types: TFC A, TFC B, TFC C, TFC D, and TFC E . Each cofactor plays a specific role in the tubulin folding pathway, ensuring the correct formation of α/β-tubulin heterodimers .
Key Biological Properties: TFCs are involved in the folding and stabilization of tubulin monomers, preventing the formation of non-functional aggregates . They are crucial for maintaining the stoichiometric balance of α- and β-tubulin .
Expression Patterns and Tissue Distribution: TFCs are ubiquitously expressed in eukaryotic cells, with varying levels depending on the tissue type and developmental stage . For instance, TFC A is highly expressed in plant cells, where it plays a significant role in microtubule organization .
Primary Biological Functions: TFCs facilitate the proper folding of tubulin monomers, leading to the formation of functional microtubules . These microtubules are essential for various cellular processes, including cell division, intracellular transport, and maintenance of cell shape .
Role in Immune Responses and Pathogen Recognition: While TFCs are primarily involved in tubulin folding, their role in immune responses and pathogen recognition is less direct. However, the proper functioning of microtubules, facilitated by TFCs, is crucial for the immune system’s ability to respond to pathogens .
Mechanisms with Other Molecules and Cells: TFCs interact with tubulin monomers and chaperonins to facilitate the correct folding of tubulin . For example, TFC B initially binds to α-tubulin, while TFC A binds to β-tubulin. These are then replaced by TFCs E and D, respectively, to form a quaternary complex .
Binding Partners and Downstream Signaling Cascades: TFCs form complexes with tubulin monomers and other cofactors to ensure the proper assembly of microtubules . The release of assembly-competent α/β-tubulin heterodimers is triggered by the binding of TFC C .
