Recombinant Proteins
Product List
TTC1 Human
Tetratricopeptide Repeat Domain 1 Human Recombinant
TTC1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
TTC32 Human
Tetratricopeptide Repeat Domain 32 Human Recombinant
TTC33 Human
Tetratricopeptide Repeat Domain 33 Human Recombinant
TTC33 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction
The Threshold of Toxicological Concern (TTC) is a risk assessment principle that establishes a generic exposure level for chemicals below which there is no appreciable risk to human health . This approach is particularly useful for assessing substances with limited toxicological data, such as impurities in food, cosmetics, and environmental contaminants . The TTC concept is often classified based on the Cramer classification scheme, which categorizes chemicals into three classes based on their chemical structure and potential toxicity .
The TTC approach itself does not have biological properties, as it is a risk assessment tool rather than a biological entity. However, it is applied to various substances that may have diverse biological properties. These substances can be distributed across different tissues and exhibit various expression patterns depending on their chemical nature and biological interactions .
The primary function of the TTC approach is to provide a preliminary risk assessment for low-level chemical exposures. It helps in identifying substances that require more detailed toxicological evaluation versus those that can be presumed to pose minimal risk . This is crucial in the context of immune responses and pathogen recognition, as it aids in prioritizing substances for further study based on their potential health impacts .
The TTC approach operates by comparing the estimated human exposure to a substance with established TTC values. These values are derived from extensive toxicological data and are categorized into low, moderate, or high toxicity . The mechanism involves assessing the chemical structure and potential interactions with biological molecules and cells to determine the likelihood of adverse effects .
Regulatory mechanisms for the TTC approach involve guidelines and frameworks established by regulatory bodies such as the European Food Safety Authority (EFSA) and the US Food and Drug Administration (FDA). These guidelines dictate how TTC values are derived and applied in risk assessments . Transcriptional regulation and post-translational modifications are not directly applicable to the TTC approach itself but are relevant to the substances being assessed .
The TTC approach has several applications in biomedical research, including the initial screening of chemicals in food safety, pharmaceuticals, and environmental health . It is also used in developing diagnostic tools and therapeutic strategies by identifying substances that require further toxicological evaluation . This approach helps streamline the risk assessment process, making it more efficient and cost-effective .
Throughout the life cycle, the TTC approach plays a critical role in ensuring the safety of various substances from development to aging and disease . By providing a preliminary assessment of potential risks, it helps in the early identification of harmful substances, thereby protecting public health and guiding regulatory decisions .
